Evidence map›Paper›PMID 25342578›Full record

ArticleJournal of geriatric psychiatry and neurology2015

Clinicopathological Study of Patients With C9ORF72-Associated Frontotemporal Dementia Presenting With Delusions.

Shunichiro Shinagawa, Georges Naasan, Anna M Karydas, Giovanni Coppola, Mochtar Pribadi, William W Seeley, John Q Trojanowski, Bruce L Miller, Lea T Grinberg

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of geriatric psychiatry and neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Toward Precision Neuropsychiatry of Dementia: Neuropsychiatric Symptoms as Multidimensional Clinical Phenotypes.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. BV-2 Microglial Cells OverexpressingFrontiers in neurology · 2020
    Article
  18. Links Between the C9orf72 Repeat Expansion and Psychiatric Symptoms.Current neurology and neuroscience reports · 2019
    Review
  19. Psychiatric symptoms in preclinical behavioural-variant frontotemporal dementia inJournal of neurology, neurosurgery, and psychiatry · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Shunichiro ShinagawaDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan.
Georges NaasanDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA.
Anna M KarydasDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA.
Giovanni CoppolaDepartment of Psychiatry, University of California, Los Angeles, CA, USA Department of Neurology, University of California, Los Angeles, CA, USA.
Mochtar PribadiDepartment of Psychiatry, University of California, Los Angeles, CA, USA Department of Neurology, University of California, Los Angeles, CA, USA.
William W SeeleyDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA Department of Pathology, University of California, San Francisco, CA, USA.
John Q TrojanowskiCenter for Neurodegenerative Disease Research, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
Bruce L MillerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA.
Lea T GrinbergDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA Department of Pathology, University of California, San Francisco, CA, USA lea.grinberg@ucsf.edu.
University of California, San Francisco · USUniversity of California, Los Angeles · USInstitute for Neurodegenerative Disorders · USJikei University School of Medicine · JPUniversity Memory and Aging Center · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0M
UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI XIE, SHARON XIANGWEN · 1991 to 2020
$35.1M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
NIA NIH HHS P01 AG019724NIA NIH HHS P01AG019724NIA NIH HHS P30 AG010124NIA NIH HHS P50 AG023501NIA NIH HHS P50AG023501NIA NIH HHS P50AG1657303
6 · The paper itself

Abstract

backgroundSeveral clinical studies point to a high prevalence of psychotic symptoms in frontotemporal dementia associated with C9ORF72 mutations, but clinicopathological studies addressing the association between C9ORF72 mutations and delusions are lacking.

methodSeventeen patients with pathologically proven frontotemporal lobar degeneration (FTLD) associated with C9ORF72 mutations were identified from Neurodegenerative Disease Brain Bank. Of the 17 cases with C9ORF72 mutation, 4 exhibited well-defined delusions. The clinical history, neurological examination, neuropsychological testing, neuroimaging analysis, and postmortem assessment of the patients with delusions were evaluated and compared with the other cases.

resultThe content of the delusions was mixed including persecution, infidelity, and grandiosity. All cases showed parkinsonism; voxel-based morphometry analysis showed greater precuneus atrophy in patients with delusions than those without delusions. All 4 had unclassifiable FTLD with TAR DNA-binding protein inclusions, with characteristics of both type A and type B. Three cases had additional τ pathology and another had α-synuclein pathology.

conclusionC9ORF72 carriers with well-defined delusions likely associated with additional pathologies and parietal atrophy in neuroimaging. Patients presenting with middle-aged onset of delusions should be screened for C9ORF72 mutations, especially if family history and parkinsonism are present.

Indexed as

AdultAgedalpha-SynucleinAtrophyAutopsyDelusionsDNA-Binding ProteinsFrontotemporal DementiaFrontotemporal Lobar DegenerationHeterozygoteHumansMaleMiddle AgedMutationNeuroimagingNeurologic Examinationalpha-SynucleinDNA-Binding Proteinstau ProteinsC9ORF72delusionfrontotemporal dementianeurodegenerationneuroimagingneuropathology

Identifiers

PMID25342578
PMCPMC4408221
OpenAlexW2157350528

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.