ReviewBritish dental journal2014
Drugs, medications and periodontal disease.
Review in British dental journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Immunomodulation as a novel treatment strategy for periodontal disease: a systematic review.BMC oral health · 2026Pooled it
- Oral manifestations in women using hormonal contraceptive methods: a systematic review.Clinical oral investigations · 2024Pooled it
- Are Inflamed Periodontal Tissues Endogenous Source of Advanced Glycation End-Products (AGEs) in Individuals with and without Diabetes Mellitus? A Systematic Review.Biomolecules · 2022Pooled it
- Is the use of contraceptives associated with periodontal diseases? A systematic review and meta-analyses.BMC women's health · 2021Pooled it
- Evaluation of plaque removal by triple-headed manual toothbrush: a randomized controlled clinical trial.BMC oral health · 2026Trial
- Using patients' oral photographs for oral hygiene motivation promotes periodontal health: a prospective randomized controlled trial.BMC oral health · 2024Trial
- Periodontal Effects of the Reversible Dipeptidyl Peptidase 1 Inhibitor Brensocatib in Bronchiectasis.JDR clinical and translational research · 2024Trial
- UHPLC-DAD-QToF-MS profiling and marker compound analysis ofRSC advances · 2026Article
- Assessment of Cardiologists' Knowledge, Attitudes, and Practices on Calcium Channel Blocker-Induced Gingival Overgrowth.Oral health & preventive dentistry · 2026Article
- Anti-Inflammatory Effect of Resiniferatoxin During Gingival Tissue Inflammation After Mechanical Pulp Damage in a Murine Experimental Model.International journal of molecular sciences · 2026Article
- Tooth show enhancement in the esthetic zone: a review and proposal a decision-making framework.The Saudi dental journal · 2025Review
- Review
- Injectable Thermosensitive Hydrogel Containing Bakuchiol Reduces Periodontal Inflammation and Alveolar Bone Loss in a Rat Model.Journal of functional biomaterials · 2025Article
- Clinical outcomes of NBF gel application in managing mucositis associated with xerostomia.Maxillofacial plastic and reconstructive surgery · 2024Article
- Evaluation of UK paediatric nephrology teams' understanding, experience and perceptions of oral health outcomes and accessibility to dental care: a mixed-methods study.Pediatric nephrology (Berlin, Germany) · 2024Article
- Immunologic burden links periodontitis to acute coronary syndrome: levels of CD4 + and CD8 + T cells in gingival granulation tissue.Clinical oral investigations · 2024Article
- Periodontal and Peri-Implant Diagnosis: Current Evidence and Future Directions.Diagnostics (Basel, Switzerland) · 2024Article
- Association of the severity and progression rate of periodontitis with systemic medication intake.Frontiers in oral health · 2024Article
- Safety evaluation of medroxyprogesterone acetate: a pharmacovigilance analysis using FDA adverse event reporting system data.Frontiers in pharmacology · 2024Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper reviews the effects that drugs may have on the gingival and periodontal tissues. Drug-induced gingival overgrowth has been recognised for over 70 years but is becoming a more prevalent occurrence with wider use of antihypertensive and immunosuppressant drugs. The anti-inflammatory steroids, non-steroidal drugs and anti-TNF-α agents might all be expected to exert a dampening effect on chronic periodontitis although the evidence is somewhat equivocal and none of these drugs has emerged as potentially valuable adjuncts to treat periodontal disease. Desquamative gingivitis is a clinical appearance of aggressive gingival inflammation with which a number of drugs have been associated and the oral contraceptives have also been implicated in the development of gingival inflammation. Patients who are prescribed bisphosphonates and anti-platelet drugs are at risk of serious side effects following more invasive dental procedures including extractions and surgical treatments although timely, conventional management of periodontal disease may be undertaken to reduce periodontal inflammation, prevent disease progression and ultimately the need for extractions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.