ArticleNucleic acids research2014
Chromosome conformation maps in fission yeast reveal cell cycle dependent sub nuclear structure.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Integrative modeling of the genome structure and dynamics in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Contributions of DNA mechanics and trans-regulation to nucleosome positioning in Schizosaccharomyces pombe and its role in co-transcriptional splicing.Epigenetics & chromatin · 2026Article
- 3D models of fungal chromosomes to enhance visual integration of omics data.NAR genomics and bioinformatics · 2023Article
- Article
- Integrating Multimorbidity into a Whole-Body Understanding of Disease Using Spatial Genomics.Results and problems in cell differentiation · 2022Article
- Bioinformatical dissection of fission yeast DNA replication origins.Open biology · 2020Article
- Repeat elements organise 3D genome structure and mediate transcription in the filamentous fungus Epichloë festucae.PLoS genetics · 2018Article
- Cell cycle: Continuous chromatin changes.Nature · 2017Article
- Linkages between changes in the 3D organization of the genome and transcription during myotube differentiation in vitro.Skeletal muscle · 2017Article
- Article
- A diffusion model for the coordination of DNA replication in Schizosaccharomyces pombe.Scientific reports · 2016Article
- An IF-FISH Approach for Covisualization of Gene Loci and Nuclear Architecture in Fission Yeast.Methods in enzymology · 2016Article
- Spatial Genome Organization and Its Emerging Role as a Potential Diagnosis Tool.Frontiers in genetics · 2016Review
- Spatial distribution of centromeres and telomeres at interphase varies among Brachypodium species.Journal of experimental botany · 2015Article
- Chromosome domain architecture and dynamic organization of the fission yeast genome.FEBS letters · 2015Review
- Data for chromosome contacts and matched transcription profiles at three cell cycle phases in the fission yeast.Genomics data · 2015Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Successful progression through the cell cycle requires spatial and temporal regulation of gene transcript levels and the number, positions and condensation levels of chromosomes. Here we present a high resolution survey of genome interactions in Schizosaccharomyces pombe using synchronized cells to investigate cell cycle dependent changes in genome organization and transcription. Cell cycle dependent interactions were captured between and within S. pombe chromosomes. Known features of genome organization (e.g. the clustering of telomeres and retrotransposon long terminal repeats (LTRs)) were observed throughout the cell cycle. There were clear correlations between transcript levels and chromosomal interactions between genes, consistent with a role for interactions in transcriptional regulation at specific stages of the cell cycle. In silico reconstructions of the chromosome organization within the S. pombe nuclei were made by polymer modeling. These models suggest that groups of genes with high and low, or differentially regulated transcript levels have preferred positions within the S. pombe nucleus. We conclude that the S. pombe nucleus is spatially divided into functional sub-nuclear domains that correlate with gene activity. The observation that chromosomal interactions are maintained even when chromosomes are fully condensed in M phase implicates genome organization in epigenetic inheritance and bookmarking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.