Evidence map›Paper›PMID 25342179›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA2015

Using the wisdom of the crowds to find critical errors in biomedical ontologies: a study of SNOMED CT.

Jonathan M Mortensen, Evan P Minty, Michael Januszyk, Timothy E Sweeney, Alan L Rector, Natalya F Noy, Mark A Musen

Abstract read
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Mapping of Crowdsourcing in Health: Systematic Review.Journal of medical Internet research · 2018
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. A Neuro-ontology for the neurological examination.BMC medical informatics and decision making · 2020
    Article
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  8. Review
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  11. Article
  12. Article
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  15. Review
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  18. Review
  19. Tracking the Remodeling of SNOMED CT's Bacterial Infectious Diseases.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2016
    Article
  20. The Drug Data to Knowledge Pipeline: Large-Scale Claims Data Classification for Pharmacologic Insight.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jonathan M MortensenStanford Center for Biomedical Informatics Research, Stanford University, Stanford, California, USA Biomedical Informatics Training Program, Stanford University, Stanford, California, USA.
Evan P MintyBiomedical Informatics Training Program, Stanford University, Stanford, California, USA Faculty of Medicine, University of Calgary, Calgary, Canada.
Michael JanuszykBiomedical Informatics Training Program, Stanford University, Stanford, California, USA.
Timothy E SweeneyStanford Center for Biomedical Informatics Research, Stanford University, Stanford, California, USA.
Alan L RectorSchool of Computer Science, University of Manchester, Manchester, UK.
Natalya F NoyStanford Center for Biomedical Informatics Research, Stanford University, Stanford, California, USA Google Inc., Mountain View, California, USA.
Mark A MusenStanford Center for Biomedical Informatics Research, Stanford University, Stanford, California, USA Biomedical Informatics Training Program, Stanford University, Stanford, California, USA.

Funding

STANFORD COMPOSITE(RMI)U54HG004028 · NHGRI · STANFORD UNIVERSITY · PI MUSEN, MARK A · 2005 to 2014
$36.2M
POSTDOCTORAL TRAINING IN MEDICAL INFORMATION SCIENCEST15LM007033 · NLM · STANFORD UNIVERSITY · PI SYLVIA KATINA PLEVRITIS · 1985 to 2026
$25.5M
Collaborative Development of Biomedical Ontologies and TerminologiesR01GM086587 · NIGMS · STANFORD UNIVERSITY · PI MUSEN, MARK A · 2009 to 2016
$4.1M
Protege: An Ontology-Development Platform for Biomedical ScientistsR01GM103316 · NIGMS · STANFORD UNIVERSITY · PI MUSEN, MARK A · 2013 to 2016
$2.1M
NHGRI NIH HHS HG004028,NHGRI NIH HHS U54 HG004028NIGMS NIH HHS GM086587NIGMS NIH HHS R01 GM086587NIGMS NIH HHS R01 GM103316NLM NIH HHS LM007033NLM NIH HHS T15 LM007033
6 · The paper itself

Abstract

objectivesThe verification of biomedical ontologies is an arduous process that typically involves peer review by subject-matter experts. This work evaluated the ability of crowdsourcing methods to detect errors in SNOMED CT (Systematized Nomenclature of Medicine Clinical Terms) and to address the challenges of scalable ontology verification.

methodsWe developed a methodology to crowdsource ontology verification that uses micro-tasking combined with a Bayesian classifier. We then conducted a prospective study in which both the crowd and domain experts verified a subset of SNOMED CT comprising 200 taxonomic relationships.

resultsThe crowd identified errors as well as any single expert at about one-quarter of the cost. The inter-rater agreement (κ) between the crowd and the experts was 0.58; the inter-rater agreement between experts themselves was 0.59, suggesting that the crowd is nearly indistinguishable from any one expert. Furthermore, the crowd identified 39 previously undiscovered, critical errors in SNOMED CT (eg, 'septic shock is a soft-tissue infection'). DISCUSSION: The results show that the crowd can indeed identify errors in SNOMED CT that experts also find, and the results suggest that our method will likely perform well on similar ontologies. The crowd may be particularly useful in situations where an expert is unavailable, budget is limited, or an ontology is too large for manual error checking. Finally, our results suggest that the online anonymous crowd could successfully complete other domain-specific tasks.

conclusionsWe have demonstrated that the crowd can address the challenges of scalable ontology verification, completing not only intuitive, common-sense tasks, but also expert-level, knowledge-intensive tasks.

Indexed as

CrowdsourcingSystematized Nomenclature of MedicineBayes TheoremBiological OntologiesDiseaseHumansbiomedical ontologycrowdsourcingontology engineeringSNOMED CT

Identifiers

PMID25342179
PMCPMC5566196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.