ArticlePaediatric drugs2015
Oral morphine weaning for neonatal abstinence syndrome at home compared with in-hospital: an observational cohort study.
Article in Paediatric drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Opioid treatment for opioid withdrawal in newborn infants.The Cochrane database of systematic reviews · 2021Pooled it
- Sedatives for opioid withdrawal in newborn infants.The Cochrane database of systematic reviews · 2021Pooled it
- Outcome reporting in neonates experiencing withdrawal following opioid exposure in pregnancy: a systematic review.Trials · 2020Pooled it
- Managing newborns at risk for neonatal abstinence syndrome (NAS)/neonatal opioid withdrawal syndrome (NOWS): Updates and emerging best practices.Paediatrics & child health · 2025Review
- La prise en charge des nouveau-nés à risque de syndrome d'abstinence néonatale et de syndrome de sevrage néonatal aux opioïdes : mises à jour et pratiques exemplaires émergentes.Paediatrics & child health · 2025Review
- Considerations and Determinants of Discharge Decisions among Prenatal Substance Exposed Infants.Child maltreatment · 2024Article
- Economic Evaluation of Interventions for Treatment of Neonatal Opioid Withdrawal Syndrome: A Review.Children (Basel, Switzerland) · 2021Review
- Continuous intravenous to oral morphine switch in very premature ventilated infants: A retrospective study on efficacy, efficiency, and tolerability.Paediatric & neonatal pain · 2019Article
- Outpatient healthcare access and utilization for neonatal abstinence syndrome children: A systematic review.Journal of clinical and translational science · 2019Article
- Neonatal abstinence syndrome: Pharmacologic strategies for the mother and infant.Seminars in perinatology · 2016Review
- Implementation of a Neonatal Abstinence Syndrome Weaning Protocol: A Multicenter Cohort Study.Pediatrics · 2015Article
- Wide Variation Found in Care of Opioid-Exposed Newborns.Academic pediatricsArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this observational study was to evaluate the safety and effectiveness of discharging stabilized neonates to complete their oral morphine weaning at home. STUDY
designThis retrospective cohort study evaluated neonates treated with oral morphine at two hospitals in London, Ontario, Canada. Neonates who completed their morphine wean in hospital were compared with neonates who completed their morphine wean following discharge from hospital (at home).
resultsThere were 80 neonates treated with oral morphine at two hospitals from 2006 to 2010. The majority (65%, 52/80) of neonates completed their morphine weaning after hospital discharge and were significantly less likely to return to hospital for further withdrawal treatment (1/52 vs. 4/28, p < 0.05). Neonates who were treated at home remained on morphine for more days (32 vs. 19 days, p < 0.01).
conclusionsWe present the first North American cohort of neonates weaned with morphine at home for neonatal abstinence syndrome (NAS). We found that more days on oral morphine resulted in fewer returns to hospital for continued withdrawal management. There was no evidence of increased effectiveness, measured by the number of returns to hospital for further NAS management with in-hospital weaning. The estimated cost savings of continued weaning upon discharge was approximately $11,000 per patient (Canadian dollars). While further prospective research is necessary, in some cases morphine weaning at home may present a safe and cost-effective strategy for NAS management.
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