ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2015
Acylcarnitines: potential implications for skeletal muscle insulin resistance.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
149 citing papers in PubMed, 3 syntheses or guidelines pooled it, 243 citations in OpenAlex.
- Pooled it
- Mitochondrial metabolites predict adverse cardiovascular events in individuals with diabetes.JCI insight · 2023Pooled it
- Individual participant data meta-analysis of metabolomics on sustained knee pain in primary osteoarthritis patients.Rheumatology (Oxford, England) · 2023Pooled it
- Determinants of increased muscle insulin sensitivity of exercise-trained versus sedentary normal weight and overweight individuals.Science advances · 2025Trial
- Impact of a weight loss and fitness intervention on exercise-associated plasma oxylipin patterns in obese, insulin-resistant, sedentary women.Physiological reports · 2020Trial
- Trial
- Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation.Journal of lipid research · 2015Trial
- Dietary Taurine Supplementation Improves Sperm Quality and Modulates Seminal Plasma Metabolism in Heat-Stressed Dairy Goat Bucks.Animals : an open access journal from MDPI · 2026Article
- Acylcarnitines Are Associated with Metabolic Syndrome and Hypertension in Two Contrasted Obese Populations.Nutrients · 2026Observational
- Gliquidone alleviates DSS-induced ulcerative colitis in rats by targeting carnitine palmitoyltransferase 1A.Journal of pharmaceutical analysis · 2026Article
- Changes in the Metabolome of Different Tissues in Response to Streptozotocin Diabetes and Mildronate Exposure: A Metabolomic Assessment.Metabolites · 2026Article
- Transcriptomic insights into aerobic exercise-mediated attenuation of high-fat diet-induced muscle wasting.Frontiers in physiology · 2026Article
- Mitochondrial Dysfunction in Type 2 Diabetes and Metabolic Syndrome: Mechanisms, Biomarkers, and Emerging Therapies.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- The Role of Gut Bacteria and Plasma Metabolites in Predicting Post-Stroke Depression in Patients with Acute Ischemic Stroke.Current neuropharmacology · 2026Article
- Comparative analysis of targeted metabolomic profiles reveals plasma metabolite differences across three Italian heavy pig breeds.Scientific reports · 2025Article
- Predictive Role of Metabolic Profiling in Rivaroxaban Efficacy for Thrombus Lysis in Atrial Fibrillation.International journal of molecular sciences · 2025Article
- p38α MAPK Regulation of Energy Metabolism in Skeletal Muscle Offers a Therapeutic Path for Type 2 Diabetes.Cells · 2025Review
- Metabolomics in cardiometabolic diseases: Key biomarkers and therapeutic implications for insulin resistance and diabetes.Journal of internal medicine · 2025Review
- Senolytic effects of a modified Gingerenone A.npj aging · 2025Article
- Adipocyte metabolic state regulates glial phagocytic function.Cell reports · 2025Article
89 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Insulin resistance may be linked to incomplete fatty acid β-oxidation and the subsequent increase in acylcarnitine species in different tissues including skeletal muscle. It is not known if acylcarnitines participate in muscle insulin resistance or simply reflect dysregulated metabolism. The aims of this study were to determine whether acylcarnitines can elicit muscle insulin resistance and to better understand the link between incomplete muscle fatty acid β-oxidation, oxidative stress, inflammation, and insulin-resistance development. Differentiated C2C12, primary mouse, and human myotubes were treated with acylcarnitines (C4:0, C14:0, C16:0) or with palmitate with or without carnitine acyltransferase inhibition by mildronate. Treatment with C4:0, C14:0, and C16:0 acylcarnitines resulted in 20-30% decrease in insulin response at the level of Akt phosphorylation and/or glucose uptake. Mildronate reversed palmitate-induced insulin resistance concomitant with an ∼25% decrease in short-chain acylcarnitine and acetylcarnitine secretion. Although proinflammatory cytokines were not affected under these conditions, oxidative stress was increased by 2-3 times by short- or long-chain acylcarnitines. Acylcarnitine-induced oxidative stress and insulin resistance were reversed by treatment with antioxidants. Results are consistent with the conclusion that incomplete muscle fatty acid β-oxidation causes acylcarnitine accumulation and associated oxidative stress, raising the possibility that these metabolites play a role in muscle insulin resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.