Observational studyBMC nephrology2014
The incidence and risk factors of acute kidney injury after hepatobiliary surgery: a prospective observational study.
Observational study in BMC nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Incidence and risk factors of acute kidney injury after abdominal surgery: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Biomarkers for assessing acute kidney injury for people who are being considered for admission to critical care: a systematic review and cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2022Pooled it
- Incidence and associations of acute kidney injury after major abdominal surgery.Intensive care medicine · 2016Pooled it
- Association between preoperative platelet count and postoperative acute kidney injury of patients undergoing abdominal surgery: a retrospective cohort analysis of the INSPIRE database.BMC anesthesiology · 2025Article
- Transfusion Thresholds and Risk Factors of Acute Kidney Injury in Gastrointestinal Oncology Surgery: Insights from a Retrospective Study.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Internal and External Validation of Machine Learning Models for Predicting Acute Kidney Injury Following Non-Cardiac Surgery Using Open Datasets.Journal of personalized medicine · 2024Article
- Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study.Intensive care medicine · 2023Observational
- Neutrophil Gelatinase-Associated Lipocalin Cutoff Value Selection and Acute Kidney Injury Classification System Determine Phenotype Allocation and Associated Outcomes.Annals of laboratory medicine · 2023Article
- Pretreatment with a novel Toll-like receptor 4 agonist attenuates renal ischemia-reperfusion injury.American journal of physiology. Renal physiology · 2023Article
- Risk factors for acute kidney injury after major abdominal surgery in the elderly aged 75 years and above.BMC nephrology · 2022Article
- NGAL/hepcidin-25 ratio and AKI subtypes in patients following cardiac surgery: a prospective observational study.Journal of nephrology · 2022Observational
- Development and validation of a risk nomogram for postoperative acute kidney injury in older patients undergoing liver resection: a pilot study.BMC anesthesiology · 2022Observational
- Development and validation of AKI prediction model in postoperative critically ill patients: a multicenter cohort study.American journal of translational research · 2022Article
- Systems analysis of miRNA biomarkers to inform drug safety.Archives of toxicology · 2021Review
- Skin autofluorescence as a novel predictor of acute kidney injury after liver resection.World journal of surgical oncology · 2021Observational
- Article
- Incidence and Predictors of Acute Kidney Injury in Patients Undergoing Elective Hepatic Resection for Malignant Tumors: A 3-year Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Comparison of the Effects of Laparoscopic and Open Surgery on Postoperative Acute Kidney Injury in Patients with Colorectal Cancer: Propensity Score Analysis.Journal of clinical medicine · 2021Article
- Association of plasma and urine NGAL with acute kidney injury after elective colorectal surgery: A cohort study.Annals of medicine and surgery (2012) · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough intraperitoneal surgery is a major operation associated with postoperative acute kidney injury (AKI), the incidence, risk factors, and long-term renal outcome are not well known. We aimed to determine the risk factors and 6 months renal outcome in patients with clinical or subclinical AKI after hepatobiliary surgery. We also assessed the validity of urine neutrophil gelatinase-associated lipocalin (NGAL) in the early detection of AKI or prediction of renal outcome.
methodsThis prospective observational study enrolled patients with normal renal function who underwent hepatobiliary surgeries. Urine and serum samples were collected for NGAL measurement.
resultsAmong 131 patients, 10 (7.6%) developed postoperative AKI. Urine NGAL at 12 h postsurgery was the most predictive parameter for the diagnosis of AKI (cutoff, 92.85 ng/mL). With the cutoff value, subclinical AKI was diagnosed in 42 (32.1%) patients. Patients with clinical AKI and those with subclinical AKI were assigned to the AKI group. The AKI group had significantly higher model for end-stage liver disease and sodium (MELD-Na) score, lower albumin level, and longer hospital stay after surgery than the non-AKI group. Older age and higher MELD-Na score were independent risk factors for the development of postoperative AKI. At 6 months postsurgery, the estimated glomerular filtration rate (eGFR) in the AKI group was significantly lower than that in the non-AKI group, although the baseline eGFR was not different. In multiple linear regression analysis, the maximum urine NGAL level during 24 h postsurgery, intraoperative fluid balance, and having liver transplantation were significantly associated with a poor 6 months renal outcome.
conclusionUrine NGAL was useful in the early diagnosis of postoperative AKI as well as in predicting the 6 months renal outcome after hepatobiliary surgery. A considerable proportion of patients developed subclinical AKI, and these patients showed worse renal outcome compared with the non-AKI group.
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