ArticleExperimental animals2015
Development of SNP markers for C57BL/6N-derived mouse inbred strains.
Article in Experimental animals, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic quality assurance and genetic monitoring of laboratory mice and rats: FELASA Working Group Report.Laboratory animals · 2020Guideline
- Multiplex Detection of SNPs for Genetic Monitoring in Laboratory Mice by Luminex xTAG Assay.Genes · 2024Article
- Using mice from different breeding sites fails to improve replicability of results from single-laboratory studies.Lab animal · 2024Article
- Gut Microbiota-mediated Alleviation of Dextran Sulfate Sodium-induced Colitis in Mice.Gastro hep advances · 2024Article
- Review
- C3H/HeNSlc mouse with low phospholipid transfer protein expression showed dyslipidemia.Scientific reports · 2023Article
- Substrain differences in Sry expression at the stage of sex determination in C57BL/6 mouse strains.The Journal of veterinary medical science · 2023Article
- Genetic quality: a complex issue for experimental study reproducibility.Transgenic research · 2022Review
- Characterization of single nucleotide polymorphisms for a forward genetics approach using genetic crosses in C57BL/6 and BALB/c substrains of mice.Experimental animals · 2022Article
- Mouse resources at the RIKEN BioResource Research Center and the National BioResource Project core facility in Japan.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Review
- Widespread discrepancy ineLife · 2022Article
- Research-Relevant Conditions and Pathology of Laboratory Mice, Rats, Gerbils, Guinea Pigs, Hamsters, Naked Mole Rats, and Rabbits.ILAR journal · 2021Review
- Substrains matter in phenotyping of C57BL/6 mice.Experimental animals · 2021Review
- A combination of genetics and microbiota influences the severity of the obesity phenotype in diet-induced obesity.Scientific reports · 2020Article
- Methodology and theoretical basis of forward genetic screening for sleep/wakefulness in mice.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Genetic differences between C57BL/6 substrains affect the process of testis differentiation in YThe Journal of veterinary medical science · 2019Article
- A comparative analysis of hepatic pathological phenotypes in C57BL/6J and C57BL/6N mouse strains in non-alcoholic steatohepatitis models.Scientific reports · 2019Article
- Immune Relevant and Immune Deficient Mice: Options and Opportunities in Translational Research.ILAR journal · 2018Review
- High fat feeding unmasks variable insulin responses in male C57BL/6 mouse substrains.The Journal of endocrinology · 2017Article
- Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium.Diabetes · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C57BL/6N inbred mice are used as the genetic background for producing knockout mice in large-scale projects worldwide; however, the genetic divergence among C57BL/6N-derived substrains has not been verified. Here, we identified novel single nucleotide polymorphisms (SNPs) specific to the C57BL/6NJ strain and selected useful SNPs for the genetic monitoring of C57BL/6N-derived substrains. Informative SNPs were selected from the public SNP database at the Wellcome Trust Sanger Institute by comparing sequence data from C57BL/6NJ and C57BL/6J mice. A total of 1,361 candidate SNPs from the SNP database could distinguish the C57BL/6NJ strain from 12 other inbred strains. We confirmed 277 C57BL/6NJ-specific SNPs including 10 nonsynonymous SNPs by direct sequencing, and selected 100 useful SNPs that cover all of the chromosomes except Y. Genotyping of 11 C57BL/6N-derived substrains at these 100 SNP loci demonstrated genetic differences among the substrains. This information will be useful for accurate genetic monitoring of mouse strains with a C57BL/6N-derived background.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.