Evidence map›Paper›PMID 25341798›Full record

Trial reportArteriosclerosis, thrombosis, and vascular biology2014

T-cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humans.

Tracey McLaughlin, Li-Fen Liu, Cindy Lamendola, Lei Shen, John Morton, Homero Rivas, Daniel Winer, Lorna Tolentino, Okmi Choi, Hong Zhang and 2 more

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Arteriosclerosis, thrombosis, and vascular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 224 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
224citing papers in PubMed, 2 pooled it
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

224 citing papers in PubMed, 2 syntheses or guidelines pooled it, 351 citations in OpenAlex.

  1. Pooled it
  2. Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
    Pooled it
  3. Trial
  4. Article
  5. Lifestyle Modification for the Management of Psoriatic Arthritis.American journal of lifestyle medicine · 2026
    Review
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164 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Tracey McLaughlinFrom the Departments of Medicine (T.L., L.-F.L., C.L.), Pathology (D.W., L.T., O.C., H.Z., M.H.Y.C., E.E.), and Surgery (J.M., H.R.), Stanford University, CA. tmclaugh@stanford.edu.
Li-Fen LiuFrom the Departments of Medicine (T.L., L.-F.L., C.L.), Pathology (D.W., L.T., O.C., H.Z., M.H.Y.C., E.E.), and Surgery (J.M., H.R.), Stanford University, CA.
Cindy LamendolaFrom the Departments of Medicine (T.L., L.-F.L., C.L.), Pathology (D.W., L.T., O.C., H.Z., M.H.Y.C., E.E.), and Surgery (J.M., H.R.), Stanford University, CA.
Lei ShenFrom the Departments of Medicine (T.L., L.-F.L., C.L.), Pathology (D.W., L.T., O.C., H.Z., M.H.Y.C., E.E.), and Surgery (J.M., H.R.), Stanford University, CA.
John MortonFrom the Departments of Medicine (T.L., L.-F.L., C.L.), Pathology (D.W., L.T., O.C., H.Z., M.H.Y.C., E.E.), and Surgery (J.M., H.R.), Stanford University, CA.
Homero RivasFrom the Departments of Medicine (T.L., L.-F.L., C.L.), Pathology (D.W., L.T., O.C., H.Z., M.H.Y.C., E.E.), and Surgery (J.M., H.R.), Stanford University, CA.
Daniel WinerFrom the Departments of Medicine (T.L., L.-F.L., C.L.), Pathology (D.W., L.T., O.C., H.Z., M.H.Y.C., E.E.), and Surgery (J.M., H.R.), Stanford University, CA.
Lorna TolentinoFrom the Departments of Medicine (T.L., L.-F.L., C.L.), Pathology (D.W., L.T., O.C., H.Z., M.H.Y.C., E.E.), and Surgery (J.M., H.R.), Stanford University, CA.
Okmi ChoiFrom the Departments of Medicine (T.L., L.-F.L., C.L.), Pathology (D.W., L.T., O.C., H.Z., M.H.Y.C., E.E.), and Surgery (J.M., H.R.), Stanford University, CA.
Hong ZhangFrom the Departments of Medicine (T.L., L.-F.L., C.L.), Pathology (D.W., L.T., O.C., H.Z., M.H.Y.C., E.E.), and Surgery (J.M., H.R.), Stanford University, CA.
Melissa Hui Yen ChngFrom the Departments of Medicine (T.L., L.-F.L., C.L.), Pathology (D.W., L.T., O.C., H.Z., M.H.Y.C., E.E.), and Surgery (J.M., H.R.), Stanford University, CA.
Edgar EnglemanFrom the Departments of Medicine (T.L., L.-F.L., C.L.), Pathology (D.W., L.T., O.C., H.Z., M.H.Y.C., E.E.), and Surgery (J.M., H.R.), Stanford University, CA.
L-3 Communications (United States) · US

Funding

Defining Adaptive Immune Mechanisms of Insulin ResistanceR01DK096038 · NIDDK · STANFORD UNIVERSITY · PI ENGLEMAN, EDGAR G. · 2012 to 2015
$1.5M
Integrating the Metabolic and Genetic Faces of ObesityR01DK071309 · NIDDK · STANFORD UNIVERSITY · PI REAVEN, GERALD M. · 2005 to 2008
$1.3M
Heterogeneity of Fat Depots: Biological Differences Related to Insulin ResistanceR01DK080436 · NIDDK · STANFORD UNIVERSITY · PI MCLAUGHLIN, TRACEY · 2009 to 2011
$1.1M
NIDDK NIH HHS DK096038NIDDK NIH HHS R01 DK071309NIDDK NIH HHS R01DK071309NIDDK NIH HHS R01 DK080436NIDDK NIH HHS R01DK080436NIDDK NIH HHS R01 DK096038
6 · The paper itself

Abstract

objectiveThe biological mechanisms linking obesity to insulin resistance have not been fully elucidated. We have shown that insulin resistance or glucose intolerance in diet-induced obese mice is related to a shift in the ratio of pro- and anti-inflammatory T cells in adipose tissue. We sought to test the hypothesis that the balance of T-cell phenotypes would be similarly related to insulin resistance in human obesity. APPROACH AND

resultsHealthy overweight or obese human subjects underwent adipose-tissue biopsies and quantification of insulin-mediated glucose disposal by the modified insulin suppression test. T-cell subsets were quantified by flow cytometry in visceral (VAT) and subcutaneous adipose tissue (SAT). Results showed that CD4 and CD8 T cells infiltrate both depots, with proinflammatory T-helper (Th)-1, Th17, and CD8 T cells, significantly more frequent in VAT as compared with SAT. T-cell profiles in SAT and VAT correlated significantly with one another and with peripheral blood. Th1 frequency in SAT and VAT correlated directly, whereas Th2 frequency in VAT correlated inversely, with plasma high-sensitivity C-reactive protein concentrations. Th2 in both depots and peripheral blood was inversely associated with systemic insulin resistance. Furthermore, Th1 in SAT correlated with plasma interleukin-6. Relative expression of associated cytokines, measured by real-time polymerase chain reaction, reflected flow cytometry results. Most notably, adipose tissue expression of anti-inflammatory interleukin-10 was inversely associated with insulin resistance.

conclusionsCD4 and CD8 T cells populate human adipose tissue and the relative frequency of Th1 and Th2 are highly associated with systemic inflammation and insulin resistance. These findings point to the adaptive immune system as a potential mediator between obesity and insulin resistance or inflammation. Identification of antigenic stimuli in adipose tissue may yield novel targets for treatment of obesity-associated metabolic disease.

Indexed as

Adipose TissueAdultAgedAnimalsCytokinesFemaleHumansInflammationInflammation MediatorsInsulin ResistanceIntra-Abdominal FatMaleMiceMiddle AgedObesityOverweightCytokinesInflammation Mediatorsadaptive immunityC-reactive proteinhuman adipose tissue-specific secretory factorinflammationinsulin resistanceinterleukin-10interleukin-6obesityT helper lymphocytesT lymphocytesvisceral fat

Identifiers

PMID25341798
PMCPMC4445971
OpenAlexW2086581449

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.