Evidence map›Paper›PMID 25341797›Full record

Trial reportArteriosclerosis, thrombosis, and vascular biology2014

Brachial flow-mediated dilation and incident atrial fibrillation: the multi-ethnic study of atherosclerosis.

Wesley T O'Neal, Jimmy T Efird, Joseph Yeboah, Saman Nazarian, Alvaro Alonso, Susan R Heckbert, Elsayed Z Soliman

Open access · bronzeAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Arteriosclerosis, thrombosis, and vascular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Wesley T O'NealFrom the Department of Internal Medicine (W.T.O.), Department of Internal Medicine, Section on Cardiology (J.Y., E.Z.S.), and Department of Epidemiology and Prevention, Epidemiological Cardiology Research Center (EPICARE) (E.Z.S.), Wake Forest School of Medicine, Winston-Salem, NC; Department of Cardiovascular Sciences, East Carolina Heart Institute, Brody School of Medicine, East Carolina University, Greenville, NC (J.T.E.); Departments of Medicine and Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (S.N.); Department of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (A.A.); and Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Group Health Research Institute, Seattle (S.R.H.). woneal@wakehealth.edu.
Jimmy T EfirdFrom the Department of Internal Medicine (W.T.O.), Department of Internal Medicine, Section on Cardiology (J.Y., E.Z.S.), and Department of Epidemiology and Prevention, Epidemiological Cardiology Research Center (EPICARE) (E.Z.S.), Wake Forest School of Medicine, Winston-Salem, NC; Department of Cardiovascular Sciences, East Carolina Heart Institute, Brody School of Medicine, East Carolina University, Greenville, NC (J.T.E.); Departments of Medicine and Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (S.N.); Department of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (A.A.); and Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Group Health Research Institute, Seattle (S.R.H.).
Joseph YeboahFrom the Department of Internal Medicine (W.T.O.), Department of Internal Medicine, Section on Cardiology (J.Y., E.Z.S.), and Department of Epidemiology and Prevention, Epidemiological Cardiology Research Center (EPICARE) (E.Z.S.), Wake Forest School of Medicine, Winston-Salem, NC; Department of Cardiovascular Sciences, East Carolina Heart Institute, Brody School of Medicine, East Carolina University, Greenville, NC (J.T.E.); Departments of Medicine and Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (S.N.); Department of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (A.A.); and Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Group Health Research Institute, Seattle (S.R.H.).
Saman NazarianFrom the Department of Internal Medicine (W.T.O.), Department of Internal Medicine, Section on Cardiology (J.Y., E.Z.S.), and Department of Epidemiology and Prevention, Epidemiological Cardiology Research Center (EPICARE) (E.Z.S.), Wake Forest School of Medicine, Winston-Salem, NC; Department of Cardiovascular Sciences, East Carolina Heart Institute, Brody School of Medicine, East Carolina University, Greenville, NC (J.T.E.); Departments of Medicine and Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (S.N.); Department of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (A.A.); and Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Group Health Research Institute, Seattle (S.R.H.).
Alvaro AlonsoFrom the Department of Internal Medicine (W.T.O.), Department of Internal Medicine, Section on Cardiology (J.Y., E.Z.S.), and Department of Epidemiology and Prevention, Epidemiological Cardiology Research Center (EPICARE) (E.Z.S.), Wake Forest School of Medicine, Winston-Salem, NC; Department of Cardiovascular Sciences, East Carolina Heart Institute, Brody School of Medicine, East Carolina University, Greenville, NC (J.T.E.); Departments of Medicine and Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (S.N.); Department of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (A.A.); and Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Group Health Research Institute, Seattle (S.R.H.).
Susan R HeckbertFrom the Department of Internal Medicine (W.T.O.), Department of Internal Medicine, Section on Cardiology (J.Y., E.Z.S.), and Department of Epidemiology and Prevention, Epidemiological Cardiology Research Center (EPICARE) (E.Z.S.), Wake Forest School of Medicine, Winston-Salem, NC; Department of Cardiovascular Sciences, East Carolina Heart Institute, Brody School of Medicine, East Carolina University, Greenville, NC (J.T.E.); Departments of Medicine and Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (S.N.); Department of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (A.A.); and Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Group Health Research Institute, Seattle (S.R.H.).
Elsayed Z SolimanFrom the Department of Internal Medicine (W.T.O.), Department of Internal Medicine, Section on Cardiology (J.Y., E.Z.S.), and Department of Epidemiology and Prevention, Epidemiological Cardiology Research Center (EPICARE) (E.Z.S.), Wake Forest School of Medicine, Winston-Salem, NC; Department of Cardiovascular Sciences, East Carolina Heart Institute, Brody School of Medicine, East Carolina University, Greenville, NC (J.T.E.); Departments of Medicine and Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (S.N.); Department of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (A.A.); and Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Group Health Research Institute, Seattle (S.R.H.).
University of Minnesota · USEast Carolina University · USJohns Hopkins Medicine · US

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-N01HC95159-268095159N01HC095159 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 1999 to 2006
$304k
Adjunctive Use of Apyrase to Fibrinolytic TherapyR43HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2009 to 2009
$226k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READINGN01HC095169 · HC · LA BIOMED RES INST/ HARBOR UCLA MED CTR · PI DETRANO, ROBERT · 1999 to 2001
$124k
NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1-RR-024156NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1-RR-025005NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95169
6 · The paper itself

Abstract

objectiveIt is unknown whether endothelial dysfunction precedes atrial fibrillation (AF) development. The objective of this study was to examine the association of brachial flow-mediated dilation (FMD) with incident AF. APPROACH AND

resultsA total of 2936 participants (mean age, 61±9.9 years; 50% women; 66% nonwhites) from the Multi-Ethnic Study of Atherosclerosis with available ultrasound brachial FMD measurements who were free of baseline AF were included in this analysis. Baseline (2000-2002) FMD was computed from the percentage difference (%FMD) in brachial artery diameter and maximum diameter during measured vasodilator response. AF was ascertained from hospitalization data including Medicare claims during a median follow-up of 8.5 years. Probability-weighted Cox proportional-hazards regression was used to compute hazard ratios and 95% confidence intervals for the association between FMD as a continuous variable (%FMD values per 1-SD increase) and incident AF. Incident AF was detected in 137 (4.7%) participants. Those with %FMD values below the sex-specific median value (median %FMD; men, 3.6%; women, 4.2%; incidence rate per 1000 person-years, 7.3; 95% confidence interval, 5.9-9.0) were more likely to develop AF than people whose %FMD values were above the median value (incidence rate per 1000 person-years, 4.5; 95% confidence interval, 3.4-5.8; log-rank P=0.0043). In a multivariable Cox regression analysis, each 1-SD increase in %FMD values (SD, 2.8%) was associated with less incident AF (hazard ratio, 0.84; 95% confidence interval, 0.70-0.99). These results were consistent across subgroups stratified by age, sex, and race/ethnicity.

conclusionsSmaller brachial FMD values are associated with higher rates of AF, suggesting a role for endothelial dysfunction in AF pathogenesis.

Indexed as

AgedAged, 80 and overAtherosclerosisAtrial FibrillationBlood Flow VelocityBrachial ArteryCohort StudiesEndothelium, VascularEthnicityFemaleFollow-Up StudiesHumansMaleMiddle AgedUltrasonographyVasodilationatrial fibrillationendotheliumepidemiology

Identifiers

PMID25341797
PMCPMC4239189
OpenAlexW2531467228

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.