Evidence map›Paper›PMID 25341696›Full record

SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2016

Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to allergic rhinitis in Chinese populations: a systematic review and meta-analysis.

Ruo-Fei Huang, Pin Dong, Tian-Zhen Zhang, Xin-Jiang Ying, Hua Hu

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruo-Fei HuangDepartment of Otolaryngology-Head and Neck Surgery, Shanghai First People's Hospital affiliated to Shanghai Jiao Tong University, 85 Wujin Road, Shanghai, 200080, China. huangruofei68@126.com.
Pin DongDepartment of Otolaryngology-Head and Neck Surgery, Shanghai First People's Hospital affiliated to Shanghai Jiao Tong University, 85 Wujin Road, Shanghai, 200080, China.
Tian-Zhen ZhangDepartment of Otolaryngology-Head and Neck Surgery, Shanghai First People's Hospital affiliated to Shanghai Jiao Tong University, 85 Wujin Road, Shanghai, 200080, China.
Xin-Jiang YingDepartment of Otolaryngology-Head and Neck Surgery, Shanghai First People's Hospital affiliated to Shanghai Jiao Tong University, 85 Wujin Road, Shanghai, 200080, China.
Hua HuDepartment of Otolaryngology-Head and Neck Surgery, Shanghai First People's Hospital affiliated to Shanghai Jiao Tong University, 85 Wujin Road, Shanghai, 200080, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In view of the controversies surrounding the angiotensin-converting enzyme (ACE)-allergic rhinitis (AR) association, a systematic review and meta-analysis of the ACE genetic association studies of AR was performed in Chinese populations. PubMed, Springer Link, OvidSP, Chinese biomedical database, Chinese national knowledge infrastructure, Chinese VIP and Wanfang databases were searched for related studies. A total of 4 studies including 415 AR patients and 309 controls were involved in this meta-analysis. Overall, significant association was found between ACE I/D polymorphism and AR risk when all studies in Chinese populations pooled into the meta-analysis (allele, OR 1.50, 95 % CI 1.19-1.90; homozygous, OR 2.59, 95 % CI 1.52-4.41, recessive, OR 2.05, 95 % CI 1.27-3.32). In the subgroup analysis by ethnicity, ACE I/D polymorphism was associated with significant elevated risks of AR in Chinese Han under homozygous and recessive models (homozygous, OR 4.36, 95 % CI 1.76-10.82, recessive, OR 2.51, 95 % CI 1.18-5.34). In conclusion, this meta-analysis provides the evidence that ACE I/D polymorphism may contribute to the AR development in Chinese populations and studies with large sample size and wider spectrum of population are warranted to verify this finding.

Indexed as

Genetic Predisposition to DiseaseINDEL MutationPolymorphism, GeneticAllelesChinaDNAHumansPeptidyl-Dipeptidase ARhinitis, AllergicACE protein, humanDNAPeptidyl-Dipeptidase AAllergic rhinitisAngiotensin-converting enzymeMeta-analysisPolymorphism

Identifiers

PMID25341696

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.