ReviewViruses2014
Arboviral bottlenecks and challenges to maintaining diversity and fitness during mosquito transmission.
Review in Viruses, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The life cycle of the alphaviruses: From an antiviral perspective.Antiviral research · 2023Pooled it
- The 3'Untranslated region is a critical determinant of Getah virus replication, pathogenesis, and vector competence.Virulence · 2026Article
- Vector competence acrossJournal of virology · 2026Review
- Intrahost population dynamics of chikungunya virus in humans and naturally infectedVirus evolution · 2026Article
- Viral expansion after transfer is a primary driver of influenza A virus transmission bottlenecks.PLoS biology · 2025Article
- Viral expansion after transfer is a primary driver of influenza A virus transmission bottlenecks.bioRxiv : the preprint server for biology · 2025Article
- Differential Virulence and Host-Specific Fitness of Regionally Distinct Human-Derived Powassan Virus Lineage 2 Strains.The American journal of tropical medicine and hygiene · 2025Article
- Article
- Evolution and adaptation of dengue virus in response to high-temperature passaging in mosquito cells.Virus evolution · 2025Article
- Obesity's Unexpected Influence: Reduced Alphavirus Transmission and Altered Immune Activation in the Vector.Journal of medical virology · 2024Article
- Evaluating vector competence for Yellow fever in the Caribbean.Nature communications · 2024Article
- Review
- Loss of West Nile virus genetic diversity during mosquito infection due to species-dependent population bottlenecks.iScience · 2023Article
- Identification and Molecular Characteristics of a Novel Single-Stranded RNA Virus Isolated from Culex tritaeniorhynchus in China.Microbiology spectrum · 2023Article
- Impact of structural dynamics on biological functions of flaviviruses.The FEBS journal · 2023Review
- Intra-Host Diversity of Dengue Virus in Mosquito Vectors.Frontiers in cellular and infection microbiology · 2022Review
- Chikungunya virus non-structural protein nsP3 interacts withVirusdisease · 2021Article
- UsingJournal of virology · 2021Review
- Rapid evolution of enhanced Zika virus virulence during direct vertebrate transmission chains.Journal of virology · 2021Article
- Population bottlenecks and founder effects: implications for mosquito-borne arboviral emergence.Nature reviews. Microbiology · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The term arbovirus denotes viruses that are transmitted by arthropods, such as ticks, mosquitoes, and other biting arthropods. The infection of these vectors produces a certain set of evolutionary pressures on the virus; involving migration from the midgut, where the blood meal containing the virus is processed, to the salivary glands, in order to transmit the virus to the next host. During this process the virus is subject to numerous bottlenecks, stochastic events that significantly reduce the number of viral particles that are able to infect the next stage. This article reviews the latest research on the bottlenecks that occur in arboviruses and the way in which these affect the evolution and fitness of these viruses. In particular we focus on the latest research on three important arboviruses, West Nile virus, Venezuelan equine encephalitis virus and Chikungunya viruses and compare the differing effects of the mosquito bottlenecks on these viruses as well as other evolutionary pressures that affect their evolution and transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.