ArticleThe international journal of cardiovascular imaging2015
Dual modality intravascular optical coherence tomography (OCT) and near-infrared fluorescence (NIRF) imaging: a fully automated algorithm for the distance-calibration of NIRF signal intensity for quantitative molecular imaging.
Article in The international journal of cardiovascular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
- Ultrathin-strut versus thin-strut stent healing and outcomes in preclinical and clinical subjects.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024Article
- Multimodal Analytical Tools to Enhance Mechanistic Understanding of Aortic Valve Calcification.The American journal of pathology · 2024Review
- Machine Learning-Assisted Short-Wave InfraRed (SWIR) Techniques for Biomedical Applications: Towards Personalized Medicine.Journal of personalized medicine · 2023Review
- Heavy macrophage infiltration identified by optical coherence tomography relates to plaque rupture.Annals of clinical and translational neurology · 2023Article
- Review
- Dual-modality fluorescence lifetime imaging-optical coherence tomography intravascular catheter system with freeform catheter optics.Journal of biomedical optics · 2022Article
- Intravascular Fluorescence Molecular Imaging of Atherosclerosis.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Highly Selective PPARα (Peroxisome Proliferator-Activated Receptor α) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging.Journal of the American Heart Association · 2021Article
- Dual-modality optical coherence tomography and fluorescence tethered capsule endomicroscopy.Biomedical optics express · 2021Article
- Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque.Theranostics · 2021Article
- Molecular and Nonmolecular Imaging of Macrophages in Atherosclerosis.Frontiers in cardiovascular medicine · 2021Review
- Paclitaxel Drug-Coated Balloon Angioplasty Suppresses Progression and Inflammation of Experimental Atherosclerosis in Rabbits.JACC. Basic to translational science · 2020Article
- Optical coherence tomography versus intravascular ultrasound in patients with myocardial infarction: a diagnostic performance study of pre-percutaneous coronary interventions.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Article
- Depth-multiplexed optical coherence tomography dual-beam manually-actuated distortion-corrected imaging (DMDI) with a micromotor catheter.Biomedical optics express · 2018Article
- Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging.Scientific reports · 2018Article
- PET Molecular Targets and Near-Infrared Fluorescence Imaging of Atherosclerosis.Current cardiology reports · 2018Review
- Simultaneous, label-free, multispectral fluorescence lifetime imaging and optical coherence tomography using a double-clad fiber.Optics letters · 2017Article
- Intravascular fibrin molecular imaging improves the detection of unhealed stents assessed by optical coherence tomography in vivo.European heart journal · 2017Article
- Fully integrated optical coherence tomography, ultrasound, and indocyanine green-based fluorescence tri-modality system for intravascular imaging.Biomedical optics express · 2017Article
- Clinical Characterization of Coronary Atherosclerosis With Dual-Modality OCT and Near-Infrared Autofluorescence Imaging.JACC. Cardiovascular imaging · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Intravascular optical coherence tomography (IVOCT) is a well-established method for the high-resolution investigation of atherosclerosis in vivo. Intravascular near-infrared fluorescence (NIRF) imaging is a novel technique for the assessment of molecular processes associated with coronary artery disease. Integration of NIRF and IVOCT technology in a single catheter provides the capability to simultaneously obtain co-localized anatomical and molecular information from the artery wall. Since NIRF signal intensity attenuates as a function of imaging catheter distance to the vessel wall, the generation of quantitative NIRF data requires an accurate measurement of the vessel wall in IVOCT images. Given that dual modality, intravascular OCT-NIRF systems acquire data at a very high frame-rate (>100 frames/s), a high number of images per pullback need to be analyzed, making manual processing of OCT-NIRF data extremely time consuming. To overcome this limitation, we developed an algorithm for the automatic distance-correction of dual-modality OCT-NIRF images. We validated this method by comparing automatic to manual segmentation results in 180 in vivo images from six New Zealand White rabbit atherosclerotic after indocyanine-green injection. A high Dice similarity coefficient was found (0.97 ± 0.03) together with an average individual A-line error of 22 µm (i.e., approximately twice the axial resolution of IVOCT) and a processing time of 44 ms per image. In a similar manner, the algorithm was validated using 120 IVOCT clinical images from eight different in vivo pullbacks in human coronary arteries. The results suggest that the proposed algorithm enables fully automatic visualization of dual modality OCT-NIRF pullbacks, and provides an accurate and efficient calibration of NIRF data for quantification of the molecular agent in the atherosclerotic vessel wall.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.