ArticleEmerging infectious diseases2014
Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups.
Article in Emerging infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 309 papers, 2 of them syntheses that pooled it.
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Who cites it
309 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review and meta-analysis on the carbapenem-resistant hypervirulent Klebsiella pneumoniae isolates.BMC pharmacology & toxicology · 2025Pooled it
- A systematic review of hypervirulentFrontiers in medicine · 2025Pooled it
- Molecular characterization of carbapenem resistance and hypervirulence determinants of Klebsiella pneumoniae circulating in a tertiary hospital in Cyprus.Molecular biology reports · 2026Article
- A fitness advantage from the pLVPK plasmid fuels the global spread of a carbapenem-resistant hypervirulent Klebsiella pneumoniae high-risk clone: ST11-KL64.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Cumulative cgMLST provides increased discrimination of nested phylogenetic groups.Genome medicine · 2026Article
- Antimicrobial resistance and plasmidome of carbapenemase-resistant Klebsiella pneumoniae causing bloodstream infections between 2014 and 2024.BMC microbiology · 2026Article
- Genomics of Hospital-Associated Brazilian Multidrug-Resistant Klebsiella pneumoniae: Abundance of Resistance and Virulence Genes and Mosaicism of the blaCurrent microbiology · 2026Article
- Genomic characterization of multidrug-resistant Klebsiella pneumoniae clinical isolates from India.Scientific reports · 2026Article
- Genomic and functional approaches point to potential determinants of neonatalMicrobiology spectrum · 2026Article
- Life Identification Numbers: A strain nomenclature approach to aid epidemiological surveillance of bacterial pathogens.PLoS biology · 2026Article
- Genomic analysis ofbioRxiv : the preprint server for biology · 2026Article
- Decentralized nanopore genomics reveals diverseMicrobial genomics · 2026Article
- Ceftazidime-avibactam for multidrug and pandrug-resistant gram-negative infections in critically Ill children: a single-center pediatric ıntensive care experience.European journal of pediatrics · 2026Observational
- Connections betweenInfection and immunity · 2026Article
- Genetically Similar High-Risk Strains of Carbapenemase-Producing Enterobacterales in Humans and Companion Animals, United States.Emerging infectious diseases · 2026Article
- Hidden burden of intestinal Klebsiella pneumoniae in Taiwan: insights into pathogenic potentials and genomic diversity.Gut pathogens · 2026Article
- Carriage of hypervirulent and ESBL-producingApplied and environmental microbiology · 2026Article
- The acquisition ofmBio · 2026Article
- Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2026Review
- Transmission dynamics of Klebsiella pneumoniae in a neonatal intensive care unit in Zambia before and after an infection control bundle.PLOS global public health · 2026Article
249 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multidrug-resistant and highly virulent Klebsiella pneumoniae isolates are emerging, but the clonal groups (CGs) corresponding to these high-risk strains have remained imprecisely defined. We aimed to identify K. pneumoniae CGs on the basis of genome-wide sequence variation and to provide a simple bioinformatics tool to extract virulence and resistance gene data from genomic data. We sequenced 48 K. pneumoniae isolates, mostly of serotypes K1 and K2, and compared the genomes with 119 publicly available genomes. A total of 694 highly conserved genes were included in a core-genome multilocus sequence typing scheme, and cluster analysis of the data enabled precise definition of globally distributed hypervirulent and multidrug-resistant CGs. In addition, we created a freely accessible database, BIGSdb-Kp, to enable rapid extraction of medically and epidemiologically relevant information from genomic sequences of K. pneumoniae. Although drug-resistant and virulent K. pneumoniae populations were largely nonoverlapping, isolates with combined virulence and resistance features were detected.
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