ArticleJournal of biomedical optics2014
Does optical microangiography provide accurate imaging of capillary vessels?: validation using multiphoton microscopy.
Article in Journal of biomedical optics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Age-related alterations in retinal capillary function.Microvascular research · 2023Article
- In Vivo Longitudinal Tracking of Lymphangiogenesis and Angiogenesis in Cutaneous Melanoma Mouse Model Using Multifunctional Optical Coherence Tomography.JID innovations : skin science from molecules to population health · 2021Article
- Quantitative research on the interaction between cerebral edema and peripheral cerebral blood perfusion using swept-source optical coherence tomography.Quantitative imaging in medicine and surgery · 2021Article
- Validation of red blood cell flux and velocity estimations based on optical coherence tomography intensity fluctuations.Scientific reports · 2020Article
- Tail artifact removal in OCT angiography images of rodent cortex.Journal of biophotonics · 2017Article
- Can OCT Angiography Be Made a Quantitative Blood Measurement Tool?Applied sciences (Basel, Switzerland) · 2017Article
- Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics.Biomedical optics express · 2017Article
- Assessment of edema volume in skin upon injury in a mouse ear model with optical coherence tomography.Lasers in medical science · 2016Article
- Review of optical coherence tomography based angiography in neuroscience.Neurophotonics · 2016Review
- In vivo tissue injury mapping using optical coherence tomography based methods.Applied optics · 2015Article
- Vasodynamics of pial and penetrating arterioles in relation to arteriolo-arteriolar anastomosis after focal stroke.Neurophotonics · 2015Article
- High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography.Lasers in surgery and medicine · 2015Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Optical microangiography (OMAG) has been extensively utilized to study three-dimensional tissue vasculature in vivo. However, with the limited image resolution (∼10 μm ) of the commonly used systems, some concerns were raised: (1) whether OMAG is capable of providing the imaging of capillary vessels that are of an average diameter of ∼6 μm ; (2) if yes, whether OMAG can provide meaningful quantification of vascular density within the scanned tissue volume. Multiphoton microscopy (MPM) is capable of depth-resolved high-resolution (∼1 μm ) imaging of biological tissue structures. With externally labeled plasma, the vascular network including single capillaries can be well visualized. We compare the vascular images of in vivo mouse brain acquired by both OMAG and MPM systems. We found that within the penetration depth range of the MPM system, OMAG is able to accurately visualize blood vessels including capillaries. Although the resolution of OMAG may not be able to 100% resolve two closely packed tiny capillaries in tissue, it is still capable of visualizing most of the capillaries because there are interstitial tissue spaces between them. We believe our validation results reinforce the application of OMAG in microvasculature-related studies.
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