ReviewAnnual review of physiology2015
Regulation of body fat in Caenorhabditis elegans.
Review in Annual review of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 94 citations in OpenAlex.
- Condensate-driven triglyceride reduction links α-synuclein to mitochondrial dysfunction.EMBO reports · 2026Article
- Size-Dependent Disruption of Lipid Metabolism by Polystyrene Micro- and Nanoplastics inToxics · 2026Article
- Oleoylethanolamine precursor triggers lipolysis during Time-Restricted Intermittent Fasting and promotes longevity and healthy aging of Caenorhabditis elegans.Journal of physiology and biochemistry · 2025Article
- Anti-Aging Effects and Mechanisms of Cod Collagen Peptides (CCPs) inJournal of functional biomaterials · 2025Article
- The Positive Effect ofNutrients · 2025Article
- ASI-RIM neuronal axis regulates systemic mitochondrial stress response via TGF-β signaling cascade.Nature communications · 2024Article
- A homeostatic gut-to-brain insulin antagonist restrains neuronally stimulated fat loss.Nature communications · 2024Article
- Starvation resistance in the nematode Pristionchus pacificus requires a conserved supplementary nuclear receptor.Zoological letters · 2024Article
- Kombucha Tea-associated microbes remodel host metabolic pathways to suppress lipid accumulation.PLoS genetics · 2024Article
- Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans.Nature communications · 2024Article
- Early exposure to a systemic stressor confers protection later in life.Nature aging · 2024Article
- Theabrownin from Wuniuzao Dark Tea Regulates Hepatic Lipid Metabolism and Gut Microbiota in Mice Fed High-Fat Diet.Nutrients · 2023Article
- 3'sialyllactose and 6'sialyllactose enhance performance in endurance-type exercise through metabolic adaptation.Food science & nutrition · 2023Article
- The Janus-Faced Role of Lipid Droplets in Aging: Insights from the Cellular Perspective.Biomolecules · 2023Review
- Stimulated Raman Scattering Imaging Sheds New Light on Lipid Droplet Biology.The journal of physical chemistry. B · 2023Article
- Application ofInternational journal of molecular sciences · 2023Review
- Insight of Silkworm Pupa Oil Regulating Oxidative Stress and Lipid Metabolism inFoods (Basel, Switzerland) · 2022Article
- Astaxanthin Induces Transcriptomic Responses Associated with Lifespan Extension inAntioxidants (Basel, Switzerland) · 2022Article
- Stearoyl-CoA desaturases sustain cholinergic excitation and copulatory robustness in metabolically agingiScience · 2022Article
- Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-typeiScience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Over the past decade, studies conducted in Caenorhabditis elegans have helped to uncover the ancient and complex origins of body fat regulation. This review highlights the powerful combination of genetics, pharmacology, and biochemistry used to study energy balance and the regulation of cellular fat metabolism in C. elegans. The complete wiring diagram of the C. elegans nervous system has been exploited to understand how the sensory nervous system regulates body fat and how food perception is coupled with the production of energy via fat metabolism. As a model organism, C. elegans also offers a unique opportunity to discover neuroendocrine factors that mediate direct communication between the nervous system and the metabolic tissues. The coming years are expected to reveal a wealth of information on the neuroendocrine control of body fat in C. elegans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.