Evidence map›Paper›PMID 25340851›Full record

ArticlePloS one2014

Fyn tyrosine kinase increases Apolipoprotein E Receptor 2 levels and phosphorylation.

Teal C Burrell, Shailaja D Divekar, Edwin J Weeber, G William Rebeck

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Teal C BurrellDepartment of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia, United States of America.
Shailaja D DivekarDepartment of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia, United States of America.
Edwin J WeeberDepartment of Molecular Pharmacology and Physiology, University of South Florida Health Byrd Alzheimer's Institute, University of South Florida, Tampa, Florida, United States of America.
G William RebeckDepartment of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia, United States of America.
Georgetown University · USUSF Health Byrd Alzheimer's Institute · US

Funding

TRANSGENIC MOUSE COREP01AG030128 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI WEEBER, EDWIN JOHN · 2009 to 2013
$9.4M
Predoctoral Training in Intergrative NeuroscienceT32NS041231 · NINDS · GEORGETOWN UNIVERSITY · PI Ludise Malkova, Ashley S VanMeter · 2001 to 2026
$6.8M
Training in Neural Injury &PlasticityT32NS041218 · NINDS · GEORGETOWN UNIVERSITY · PI MARK P BURNS, Kathleen Anne Maguire-Zeiss · 2001 to 2026
$3.5M
ApOE effects on neuron signaling and function via ApoER2R01AG035379 · NIA · GEORGETOWN UNIVERSITY · PI REBECK, G WILLIAM · 2010 to 2014
$2.7M
NIA NIH HHS P01 AG030128NIA NIH HHS R01 AG030128NIA NIH HHS R01 AG035379NINDS NIH HHS T32 NS041218NINDS NIH HHS T32 NS041231
6 · The paper itself

Abstract

Apolipoprotein E Receptor 2 (ApoER2) and the tyrosine kinase Fyn are both members of the Reelin pathway, a signaling pathway essential for the laminar formation of the cortex during development and proper dendritic spine density and long-term potential (LTP) in the adult brain. In the presence of extracellular Reelin, ApoER2 binds the intracellular protein Dab1, an adaptor protein that is phosphorylated by Fyn. However, direct interactions between ApoER2 and Fyn are not well defined. Here, we show that total levels of ApoER2 and surface levels of ApoER2 are increased by active Fyn. Via a separate mechanism, ApoER2 is also phosphorylated by Fyn, an event that peaks in the postnatal cortex at day 5 and can occur at multiple ApoER2 tyrosine residues. Dab1 is also involved in this phosphorylation, promoting the phosphorylation of ApoER2 by Fyn when it is itself phosphorylated. These results elucidate some of the intracellular mechanisms that give rise to a functional Reelin pathway.

Indexed as

AnimalsBiotinylationBrainChlorocebus aethiopsCOS CellsGene Expression RegulationLDL-Receptor Related ProteinsLong-Term PotentiationMiceMice, Inbred C57BLMice, KnockoutNeuronsPhosphorylationProtein BindingProto-Oncogene Proteins c-fynRatsFyn protein, mouseFyn protein, ratLDL-Receptor Related Proteinslow density lipoprotein receptor-related protein 8Proto-Oncogene Proteins c-fynReelin ProteinReln protein, mouseReln protein, rat

Identifiers

PMID25340851
PMCPMC4207760
OpenAlexW2089195221

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.