ArticlePLoS genetics2014
Ancient expansion of the hox cluster in lepidoptera generated four homeobox genes implicated in extra-embryonic tissue formation.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 67 citations in OpenAlex.
- Escaping Constraints to Innovate: Maternal Neofunctionalization in a HoxB4 Duplicate.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2026Article
- A single-cell atlas of the bobtail squid visual and nervous system highlights molecular principles of convergent evolution.Nature ecology & evolution · 2025Article
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- Diversity, duplication, and genomic organization of homeobox genes in Lepidoptera.Genome research · 2023Article
- Multiscale analysis of the randomization limits of the chromosomal gene organization between Lepidoptera and Diptera.Proceedings. Biological sciences · 2022Article
- Identification of sex-biased and neurodevelopment genesFrontiers in physiology · 2022Article
- Early embryonic development of Bombyx.Development genes and evolution · 2021Review
- Dynamic Molecular Evolution of Mammalian Homeobox Genes: Duplication, Loss, Divergence and Gene Conversion Sculpt PRD Class Repertoires.Journal of molecular evolution · 2021Article
- Large-scale comparative analysis of cytogenetic markers across Lepidoptera.Scientific reports · 2021Article
- Draft Genome Assemblies and Annotations of Agrypnia vestita Walker, and Hesperophylax magnus Banks Reveal Substantial Repetitive Element Expansion in Tube Case-Making Caddisflies (Insecta: Trichoptera).Genome biology and evolution · 2021Article
- Unexpected mutual regulation underlies paralogue functional diversification and promotes epithelial tissue maturation in Tribolium.Communications biology · 2020Article
- Millipede genomes reveal unique adaptations during myriapod evolution.PLoS biology · 2020Article
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- Annotated Draft Genomes of Two Caddisfly Species Plectrocnemia conspersa CURTIS and Hydropsyche tenuis NAVAS (Insecta: Trichoptera).Genome biology and evolution · 2019Article
- The genome of an underwater architect, the caddisfly Stenopsyche tienmushanensis Hwang (Insecta: Trichoptera).GigaScience · 2018Article
- Multiple large-scale gene and genome duplications during the evolution of hexapods.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The deep conservation of the Lepidoptera Z chromosome suggests a non-canonical origin of the W.Nature communications · 2017Article
- New genes from old: asymmetric divergence of gene duplicates and the evolution of development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
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7 authors at 3 institutions in 1 country.
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Abstract
Gene duplications within the conserved Hox cluster are rare in animal evolution, but in Lepidoptera an array of divergent Hox-related genes (Shx genes) has been reported between pb and zen. Here, we use genome sequencing of five lepidopteran species (Polygonia c-album, Pararge aegeria, Callimorpha dominula, Cameraria ohridella, Hepialus sylvina) plus a caddisfly outgroup (Glyphotaelius pellucidus) to trace the evolution of the lepidopteran Shx genes. We demonstrate that Shx genes originated by tandem duplication of zen early in the evolution of large clade Ditrysia; Shx are not found in a caddisfly and a member of the basally diverging Hepialidae (swift moths). Four distinct Shx genes were generated early in ditrysian evolution, and were stably retained in all descendent Lepidoptera except the silkmoth which has additional duplications. Despite extensive sequence divergence, molecular modelling indicates that all four Shx genes have the potential to encode stable homeodomains. The four Shx genes have distinct spatiotemporal expression patterns in early development of the Speckled Wood butterfly (Pararge aegeria), with ShxC demarcating the future sites of extraembryonic tissue formation via strikingly localised maternal RNA in the oocyte. All four genes are also expressed in presumptive serosal cells, prior to the onset of zen expression. Lepidopteran Shx genes represent an unusual example of Hox cluster expansion and integration of novel genes into ancient developmental regulatory networks.
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