ArticlePLoS pathogens2014
Chromobacterium Csp_P reduces malaria and dengue infection in vector mosquitoes and has entomopathogenic and in vitro anti-pathogen activities.
Article in PLoS pathogens, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 184 papers.
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Who cites it
184 citing papers in PubMed, 332 citations in OpenAlex.
- Advances in mosquito gut microbiota: Mechanisms of regulating pathogen transmission and applications in vector control.Virulence · 2026Review
- Mosquito-based malaria control through genetic, microbial and immunological innovations.Nature reviews. Microbiology · 2026Review
- The Adult Aedes aegypti Bacterial Microbiota is Robust to Infection with the Obligate Microsporidian Parasite Edhazardia aedis.Environmental microbiology · 2026Article
- Drivers of Mosquito Microbiome Composition: Effects of Species, Locality, Season, and Plasmodium Infection.Microbial ecology · 2026Article
- Unlocking new frontiers in vector control strategies using Aedes aegypti microbiota.Parasites & vectors · 2026Review
- A broad-spectrum Chromobacterium biolarvicide formulation disrupts mosquito development through gut damage and apoptotic cell death and compromises vector competence.Communications biology · 2026Article
- Crop: The Black Box of Mosquito Vector Fitness.Insects · 2026Review
- Addition of a single bacterial isolate to conventional larval rearing water can impact wing size and longevity in adult malebioRxiv : the preprint server for biology · 2026Article
- Blood feeding, microbiota, and layered mosquito immunity: from pathway phenotypes to vector competence.Frontiers in immunology · 2026Review
- Article
- Effects of avian Plasmodium exposure on the microbiota of Culex pipiens.Scientific reports · 2025Article
- Mosquito host background impacts microbiome-Zika virus interactions in field- and laboratory-reared Aedes aegypti.Animal microbiome · 2025Article
- Article
- Midgut microbiota diversity and interactions shift when field Aedes aegypti mosquitoes carry the wMel strain of Wolbachia pipientis.Communications biology · 2025Article
- Microbiome diversity in mosquitoes and sand flies: implications for vector competence.Parasites & vectors · 2025Review
- Hologenomic structure of bacterial and fungal community composition in the West Nile virus vectorbioRxiv : the preprint server for biology · 2025Article
- Leveraging microbial ecology for mosquito-borne disease control.Trends in parasitology · 2025Review
- Emerging challenges for mosquito-borne disease control and the promise of symbiont-based transmission-blocking strategies.PLoS pathogens · 2025Review
- The essential role of gut microbiota in dsRNA-mediated pest control of the phytophagous ladybird beetle, Henosepilachna vigintioctopunctata.NPJ biofilms and microbiomes · 2025Article
- Article
124 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Plasmodium and dengue virus, the causative agents of the two most devastating vector-borne diseases, malaria and dengue, are transmitted by the two most important mosquito vectors, Anopheles gambiae and Aedes aegypti, respectively. Insect-bacteria associations have been shown to influence vector competence for human pathogens through multi-faceted actions that include the elicitation of the insect immune system, pathogen sequestration by microbes, and bacteria-produced anti-pathogenic factors. These influences make the mosquito microbiota highly interesting from a disease control perspective. Here we present a bacterium of the genus Chromobacterium (Csp_P), which was isolated from the midgut of field-caught Aedes aegypti. Csp_P can effectively colonize the mosquito midgut when introduced through an artificial nectar meal, and it also inhibits the growth of other members of the midgut microbiota. Csp_P colonization of the midgut tissue activates mosquito immune responses, and Csp_P exposure dramatically reduces the survival of both the larval and adult stages. Ingestion of Csp_P by the mosquito significantly reduces its susceptibility to Plasmodium falciparum and dengue virus infection, thereby compromising the mosquito's vector competence. This bacterium also exerts in vitro anti-Plasmodium and anti-dengue activities, which appear to be mediated through Csp_P -produced stable bioactive factors with transmission-blocking and therapeutic potential. The anti-pathogen and entomopathogenic properties of Csp_P render it a potential candidate for the development of malaria and dengue control strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.