ReviewEuropean cells & materials2014
Col2CreER(T2), a mouse model for a chondrocyte-specific and inducible gene deletion.
Review in European cells & materials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Deficiency of the mCellular and molecular life sciences : CMLS · 2026Article
- A census of the lung: CellCards from LungMAP.Developmental cell · 2022Article
- Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Spatial distribution of type II collagen gene expression in the mouse intervertebral disc.JOR spine · 2019Article
- Characterization of Cre recombinase mouse lines enabling cell type-specific targeting of postnatal intervertebral discs.Journal of cellular physiology · 2019Article
- Activation of β-catenin signaling in aggrecan-expressing cells in temporomandibular joint causes osteoarthritis-like defects.International journal of oral science · 2018Article
- Postnatal deletion of Alk5 gene in meniscal cartilage accelerates age-dependent meniscal degeneration in mice.Journal of cellular physiology · 2018Article
- Deletion of Runx2 in Articular Chondrocytes Decelerates the Progression of DMM-Induced Osteoarthritis in Adult Mice.Scientific reports · 2017Article
- Specific Deletion of β-Catenin inInternational journal of biological sciences · 2017Article
- Targeting the annulus fibrosus of the intervertebral disc: Col1a2-Cre(ER)T mice show specific activity of Cre recombinase in the outer annulus fibrosus.Journal of cell communication and signaling · 2016Article
- Conditional Deletion of Fgfr3 in Chondrocytes leads to Osteoarthritis-like Defects in Temporomandibular Joint of Adult Mice.Scientific reports · 2016Article
- Chondrocytes-Specific Expression of Osteoprotegerin Modulates Osteoclast Formation in Metaphyseal Bone.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
In 2007 and 2008, we published two articles reporting a tamoxifen (TM)-inducible, chondrocyte-specific gene-targeting mouse model in which the expression of CreER(T2) is driven by the type II collagen promoter (Col2CreER(T2)). The fusion protein is specifically expressed and translocated into the nucleus upon TM administration, which in turn triggers gene recombination. Since then, this animal model has become a powerful tool to study the molecular mechanism of skeletal development and degenerative cartilage diseases, including knee joint osteoarthritis (OA), temporomandibular joint (TMJ) OA, and intervertebral disc (IVD) degeneration. In this review article, we summarise the application of Col2CreER(T2) mice and discuss the potential usage of this animal model in a broad spectrum of cartilage development and molecular pathology studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.