ArticlePloS one2014
New insights into regulation of proteome and polysaccharide in cell wall of Elsholtzia splendens in response to copper stress.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- Physiological and Proteomic Analysis of Sorghum Bicolor Seedling Leaves Reveals Molecular Responses to PEG-Induced Drought Stress.Plants (Basel, Switzerland) · 2026Article
- The mitigation mechanism of exogenous pyridoxal-5-phosphate on Pb stress damage in Polygonatum Cyrtonema Hua by multi-omics combined analysis.BMC genomics · 2026Article
- AI-Integrated Omics Analysis Reveals Cultivar-Specific Resistance Mechanisms to Powdery Mildew inInternational journal of molecular sciences · 2025Article
- Review
- Heavy Metal Induced Oxidative Stress Mitigation and ROS Scavenging in Plants.Plants (Basel, Switzerland) · 2023Review
- Rare Earth Elements (REEs) Adsorption and Detoxification Mechanisms in Cell Wall Polysaccharides ofPlants (Basel, Switzerland) · 2023Article
- The Role of Hemicellulose in Cadmium Tolerance in Ramie (Plants (Basel, Switzerland) · 2022Article
- Unraveling the Genome of a High Yielding Colombian Sugarcane Hybrid.Frontiers in plant science · 2021Article
- Decoding Heavy Metal Stress Signalling in Plants: Towards Improved Food Security and Safety.Plants (Basel, Switzerland) · 2020Review
- Structural Adaptation and Physiological Mechanisms in the Leaves ofPlants (Basel, Switzerland) · 2020Article
- Excess Copper-Induced Alterations of Protein Profiles and Related Physiological Parameters in Citrus Leaves.Plants (Basel, Switzerland) · 2020Article
- Intake of Fish Oil Specifically Modulates Colonic Muc2 Expression in Middle-Aged Rats by Suppressing the Glycosylation Process.Molecular nutrition & food research · 2018Article
- Copper-resistant bacteria reduces oxidative stress and uptake of copper in lentil plants: potential for bacterial bioremediation.Environmental science and pollution research international · 2016Article
- Identification of Key Proteins and Networks Related to Grain Development in Wheat (Triticum aestivum L.) by Comparative Transcription and Proteomic Analysis of Allelic Variants in TaGW2-6A.Frontiers in plant science · 2016Article
- Cell Wall Metabolism in Response to Abiotic Stress.Plants (Basel, Switzerland) · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsCopper (Cu) is an essential micronutrient for plants. However, excess amounts of Cu are toxic and result in a wide range of harmful effects on the physiological and biochemical processes of plants. Cell wall has a crucial role in plant defense response to toxic metals. To date, the process of cell wall response to Cu and the detoxification mechanism have not been well documented at the proteomic level.
methodsAn recently developed 6-plex Tandem Mass Tag was used for relative and absolute quantitation methods to achieve a comprehensive understanding of Cu tolerance/detoxification molecular mechanisms in the cell wall. LC-MS/MS approach was performed to analyze the Cu-responsive cell wall proteins and polysaccharides. KEY
resultsThe majority of the 22 up-regulated proteins were involved in the antioxidant defense pathway, cell wall polysaccharide remodeling, and cell metabolism process. Changes in polysaccharide amount, composition, and distribution could offer more binding sites for Cu ions. The 33 down-regulated proteins were involved in the signal pathway, energy, and protein synthesis.
conclusionsBased on the abundant changes in proteins and polysaccharides, and their putative functions, a possible protein interaction network can provide new insights into Cu stress response in root cell wall. Cu can facilitate further functional research on target proteins associated with metal response in the cell wall.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.