Trial reportPloS one2014
Whole grain rye intake, reflected by a biomarker, is associated with favorable blood lipid outcomes in subjects with the metabolic syndrome--a randomized study.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00992641 (The Effect of Nordic Diet Rich in Whole Grain, Berries, Fruits, Vegetables and Fish on Features of Metabolic Syndrome - a Systems Biology Approach), which is not on this map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Nordic Diet Rich in Whole Grain, Berries, Fruits, Vegetables and Fish on Features of Metabolic Syndrome - a Systems Biology Approach
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Whole grain food diet slightly reduces cardiovascular risks in obese/overweight adults: a systematic review and meta-analysis.BMC cardiovascular disorders · 2020Pooled it
- The effect of healthy Nordic diet on cardio-metabolic markers: a systematic review and meta-analysis of randomized controlled clinical trials.European journal of nutrition · 2019Pooled it
- Pooled it
- Trial
- Effects of wheat, rye, and triticale grains on digestion, fecal quality, and health parameters in dogs.BMC veterinary research · 2026Article
- Impact of dietary transitions on overweight and obesity burden and future trends among Chinese adults.NPJ science of food · 2025Article
- Nutritional Values and Biochemical Traits of Rye (Foods (Basel, Switzerland) · 2025Article
- Nutrient intake and adherence to the Nordic nutrition recommendations in a Swedish cohort with abdominal obesity.Nutrition and health · 2024Article
- Dietary assessment of type 2 diabetic patients using healthful plant-based diet score in the Eastern Province of Saudi Arabia.BMC nutrition · 2024Article
- Effects of a wholegrain-rich diet on markers of colonic fermentation and bowel function and their associations with the gut microbiome: a randomised controlled cross-over trial.Frontiers in nutrition · 2023Article
- Wholegrain intake, growth and metabolic markers in Danish infants and toddlers: a longitudinal study.European journal of nutrition · 2022Article
- The Effect of Rye-Based Foods on Postprandial Plasma Insulin Concentration: The Rye Factor.Frontiers in nutrition · 2022Review
- Preliminary Study on Pasta Samples Characterized in Antioxidant Compounds and Their Biological Activity on Kidney Cells.Nutrients · 2021Article
- Impact of a Fermented High-Fiber Rye Diet onFrontiers in nutrition · 2020Article
- Contribution of gut microbiota to metabolism of dietary glycine betaine in mice and in vitro colonic fermentation.Microbiome · 2019Article
- Biomarkers of cereal food intake.Genes & nutrition · 2019Review
- Identification and heterologous reconstitution of a 5-alk(en)ylresorcinol synthase from endophytic fungus Shiraia sp. Slf14.Journal of microbiology (Seoul, Korea) · 2018Article
- Diet Quality, Physical Activity, and Weight Changes and Their Association With 6-Year Risk of Metabolic Syndrome in Mexican Adults.American journal of lifestyle medicineArticle
- Ancient Wheat Diet Delays Diabetes Development in a Type 2 Diabetes Animal Model.The review of diabetic studies : RDSArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 12 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimFew studies have explored the possible plasma cholesterol lowering effects of rye consumption. The aim of this secondary analysis in the SYSDIET study was to investigate the association between plasma alkylresorcinols (AR), a biomarker for whole grain wheat and rye intake, and blood lipid concentrations in a population with metabolic syndrome. Furthermore, we analyzed the associations between the AR C17:0/C21:0 ratio, a suggested marker of the relative intake of whole grain/bran rye, and blood lipid concentrations.
methodsParticipants were 30-65 years of age, with body mass index (BMI) 27-40 kg/m2 and had metabolic syndrome. Individuals were recruited through six centers in the Nordic countries and randomized either to a healthy Nordic diet (ND, n = 93), rich in whole grain rye and wheat, as well as berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products, or a control diet (n = 65) for 18/24 weeks. Associations between total plasma AR concentration and C17:0/C21:0 homologue ratio and blood lipids were investigated in pooled (ND + control group) regression analyses at 18/24 weeks adjusted for baseline value for the dependent variable, age, BMI and statin use.
resultsWhen adjusted for confounders, total plasma AR at 18/24 weeks was not significantly associated with blood lipids but the AR ratio C17:0/C21:0 was inversely associated with LDL cholesterol concentrations (B (95% CI): -0.41 (-0.80 to -0.02)), log LDL/HDL cholesterol ratio (-0.20 (-0.37 to -0.03)), log non-HDL cholesterol (-0.20 (-0.37 to -0.03)), log apolipoprotein B (-0.12 (-0.24 to 0.00)) and log triglyceride concentrations (-0.35 (-0.59 to -0.12)). DISCUSSION: Increased proportion of whole grain rye, reflected by a biomarker, in the diet is associated with favorable blood lipid outcomes, a relationship that should be further investigated.
trial registrationClinicalTrials.gov NCT00992641.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.