ArticlePloS one2014
Detection of the virulent form of AVR3a from Phytophthora infestans following artificial evolution of potato resistance gene R3a.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Solanum bulbocastanum nucleotide-binding leucine-rich repeat receptor evolution reveals functional variants and critical residues in Rpi-blb1/RB.Journal of integrative plant biology · 2025Article
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- Deciphering the Molecular Interplay Between RXLR-EncodedInternational journal of molecular sciences · 2025Review
- Altering Specificity and Autoactivity of Plant Immune Receptors Sr33 and Sr50 Via a Rational Engineering Approach.Molecular plant-microbe interactions : MPMI · 2023Article
- Identification and transfer of a new Pm21 haplotype with high genetic diversity and a special molecular resistance mechanism.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- The helper NLR immune protein NRC3 mediates the hypersensitive cell death caused by the cell-surface receptor Cf-4.PLoS genetics · 2022Article
- Thirty years of resistance: Zig-zag through the plant immune system.The Plant cell · 2022Review
- "Core" RxLR effectors in phytopathogenic oomycetes: A promising way to breeding for durable resistance in plants?Virulence · 2021Article
- Fight Hard or Die Trying: Current Status of Lipid Signaling during Plant-Pathogen Interaction.Plants (Basel, Switzerland) · 2021Review
- Identification of Natural Resistance Mediated by Recognition ofFrontiers in plant science · 2020Article
- Mapping the H2 resistance effective against Globodera pallida pathotype Pa1 in tetraploid potato.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- An RXLR effector secreted by Phytophthora parasitica is a virulence factor and triggers cell death in various plants.Molecular plant pathology · 2019Article
- Recent advances in developing disease resistance in plants.F1000Research · 2019Review
- Time-resolved dual transcriptomics reveal early induced Nicotiana benthamiana root genes and conserved infection-promoting Phytophthora palmivora effectors.BMC biology · 2017Article
- Non-host Plant Resistance againstFrontiers in plant science · 2017Article
- SGT1 is required in PcINF1/SRC2-1 induced pepper defense response by interacting with SRC2-1.Scientific reports · 2016Article
- Article
- Comparative Analysis of the Flax Immune Receptors L6 and L7 Suggests an Equilibrium-Based Switch Activation Model.The Plant cell · 2016Article
- Host-mediated gene silencing of a single effector gene from the potato pathogen Phytophthora infestans imparts partial resistance to late blight disease.Functional & integrative genomics · 2015Article
- Oomycete interactions with plants: infection strategies and resistance principles.Microbiology and molecular biology reviews : MMBR · 2015Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Engineering resistance genes to gain effector recognition is emerging as an important step in attaining broad, durable resistance. We engineered potato resistance gene R3a to gain recognition of the virulent AVR3aEM effector form of Phytophthora infestans. Random mutagenesis, gene shuffling and site-directed mutagenesis of R3a were conducted to produce R3a* variants with gain of recognition towards AVR3aEM. Programmed cell death following gain of recognition was enhanced in iterative rounds of artificial evolution and neared levels observed for recognition of AVR3aKI by R3a. We demonstrated that R3a*-mediated recognition responses, like for R3a, are dependent on SGT1 and HSP90. In addition, this gain of response is associated with re-localisation of R3a* variants from the cytoplasm to late endosomes when co-expressed with either AVR3aKI or AVR3aEM a mechanism that was previously only seen for R3a upon co-infiltration with AVR3aKI. Similarly, AVR3aEM specifically re-localised to the same vesicles upon recognition by R3a* variants, but not with R3a. R3a and R3a* provide resistance to P. infestans isolates expressing AVR3aKI but not those homozygous for AVR3aEM.
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