Evidence map›Paper›PMID 25340509›Full record

ArticlePloS one2014

A colloidal singularity reveals the crucial role of colloidal stability for nanomaterials in-vitro toxicity testing: nZVI-microalgae colloidal system as a case study.

Soledad Gonzalo, Veronica Llaneza, Gerardo Pulido-Reyes, Francisca Fernández-Piñas, Jean Claude Bonzongo, Francisco Leganes, Roberto Rosal, Eloy García-Calvo, Ismael Rodea-Palomares

Abstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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  3. Article
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  6. Stress and Protists: No life without stress.European journal of protistology · 2016
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Soledad GonzaloDepartamento de Ingeniería Química, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
Veronica LlanezaDepartment of Environmental Engineering Sciences, University of Florida, Gainesville, Florida, United States of America.
Gerardo Pulido-ReyesDepartamento de Ingeniería Química, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain; Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain.
Francisca Fernández-PiñasDepartamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain.
Jean Claude BonzongoDepartment of Environmental Engineering Sciences, University of Florida, Gainesville, Florida, United States of America.
Francisco LeganesDepartamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain.
Roberto RosalDepartamento de Ingeniería Química, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain; Instituto Madrileño de Estudios Avanzados (IMDEA) Agua, Alcalá de Henares, Madrid, Spain.
Eloy García-CalvoDepartamento de Ingeniería Química, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain; Instituto Madrileño de Estudios Avanzados (IMDEA) Agua, Alcalá de Henares, Madrid, Spain.
Ismael Rodea-PalomaresDepartamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aggregation raises attention in Nanotoxicology due to its methodological implications. Aggregation is a physical symptom of a more general physicochemical condition of colloidal particles, namely, colloidal stability. Colloidal stability is a global indicator of the tendency of a system to reduce its net surface energy, which may be achieved by homo-aggregation or hetero-aggregation, including location at bio-interfaces. However, the role of colloidal stability as a driver of ENM bioactivity has received little consideration thus far. In the present work, which focuses on the toxicity of nanoscaled Fe° nanoparticles (nZVI) towards a model microalga, we demonstrate that colloidal stability is a fundamental driver of ENM bioactivity, comprehensively accounting for otherwise inexplicable differential biological effects. The present work throws light on basic aspects of Nanotoxicology, and reveals a key factor which may reconcile contradictory results on the influence of aggregation in bioactivity of ENMs.

Indexed as

Cell CycleChemical PhenomenaColloidsIronMicroalgaeNanoparticlesReactive Oxygen SpeciesSuspensionsToxicity TestsColloidsIronReactive Oxygen SpeciesSuspensions

Identifiers

PMID25340509
PMCPMC4207682

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.