Evidence map›Paper›PMID 25340494›Full record

ArticleMedicine2014

Cortical metabolic arrangement during olfactory processing: proposal for a 18F FDG PET/CT methodological approach.

Alessandro Micarelli, Marco Pagani, Agostino Chiaravalloti, Ernesto Bruno, Isabella Pavone, Matteo Candidi, Roberta Danieli, Orazio Schillaci, Marco Alessandrini

Abstract read
In one paragraph

Article in Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. A comprehensive review of imaging findings in COVID-19 - status in early 2021.European journal of nuclear medicine and molecular imaging · 2021
    Review
  4. Academic radiology · 2020
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alessandro MicarelliDepartment of Clinical Sciences and Translational Medicine (AM, EB, IP, MA), Tor Vergata University; Institute of Cognitive Sciences and Technologies-CNR (MP), Rome, Italy; Department of Nuclear Medicine (MP), Karolinska University Hospital, Stockholm, Sweden; Department of Biomedicine and Prevention (AC, RD, OS), Tor Vergata University; Department of Psychology (MC), "Sapienza" University, Rome; and IRCCS Neuromed (OS), Pozzilli, Italy.
Marco Pagani
Agostino Chiaravalloti
Ernesto Bruno
Isabella Pavone
Matteo Candidi
Roberta Danieli
Orazio Schillaci
Marco Alessandrini

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this article is to investigate the cortical metabolic arrangements in olfactory processing by using F fluorodeoxyglucose (FDG) positron emission tomography/computed tomography.Twenty-six normosmic individuals (14 women and 12 men; mean age 46.7 ± 10 years) were exposed to a neutral olfactory condition (NC) and, after 1 month, to a pure olfactory condition (OC) in a relatively ecological environment, that is, outside the scanner. All the subjects were injected with 185-210 megabecquerel of F FDG during both stimulations. Statistical parametric mapping version 2 was used in order to assess differences between NC and OC.As a result, we found a significant higher glucose consumption during OC in the cuneus, lingual, and parahippocampal gyri, mainly in the left hemisphere. During NC, our results show a relative higher glucose metabolism in the left superior, inferior, middle, medial frontal, and orbital gyri as well as in the anterior cingulate cortex.The present investigation, performed with a widely available functional imaging clinical tool, may help to better understand the neural responses associated to olfactory processing in healthy individuals and in patients with olfactory disorders by acquiring data in an ecologic, noise-free, and resting condition in which possible cerebral activations related to unwanted attentional processes might be avoided.

Indexed as

Fluorodeoxyglucose F18Olfactory PathwaysAdultBrain MappingCerebral CortexFemaleHumansImage Interpretation, Computer-AssistedMaleMiddle AgedPositron-Emission TomographyRadiopharmaceuticalsTomography, X-Ray ComputedFluorodeoxyglucose F18Radiopharmaceuticals

Identifiers

PMID25340494
PMCPMC4616321

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.