Evidence map›Paper›PMID 25340395›Full record

ArticlePloS one2014

Prognostic influence of pre-operative C-reactive protein in node-negative breast cancer patients.

Isabel Sicking, Karolina Edlund, Eva Wesbuer, Veronika Weyer, Marco J Battista, Antje Lebrecht, Christine Solbach, Marianna Grinberg, Johannes Lotz, Gerald Hoffmann and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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  17. Obesity-associated cancer risk: the role of intestinal microbiota in the etiology of the host proinflammatory state.Translational research : the journal of laboratory and clinical medicine · 2017
    Review
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  20. Obesity and Cancer Mechanisms: Tumor Microenvironment and Inflammation.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Isabel SickingDepartment of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz, Germany.
Karolina EdlundLeibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund University of Technology, Dortmund, Germany.
Eva WesbuerDepartment of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz, Germany.
Veronika WeyerInstitute of Medical Biometry, Epidemiology and Informatics (IMBEI), Johannes Gutenberg University, Mainz, Germany.
Marco J BattistaDepartment of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz, Germany.
Antje LebrechtDepartment of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz, Germany.
Christine SolbachDepartment of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz, Germany.
Marianna GrinbergDepartment of Statistics, Dortmund University of Technology, Dortmund, Germany.
Johannes LotzInstitute for Clinical Chemistry, Johannes Gutenberg University, Mainz, Germany.
Gerald HoffmannDepartment of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz, Germany.
Jörg RahnenführerDepartment of Statistics, Dortmund University of Technology, Dortmund, Germany.
Jan G HengstlerLeibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund University of Technology, Dortmund, Germany.
Marcus SchmidtDepartment of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz, Germany.
Johannes Gutenberg University Mainz · DETU Dortmund University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The importance of inflammation is increasingly noticed in cancer. The aim of this study was to analyze the prognostic influence of pre-operative serum C-reactive protein (CRP) in a cohort of 148 lymph node-negative breast cancer patients. The prognostic significance of CRP level for disease-free survival (DFS), metastasis-free survival (MFS) and overall survival (OS) was evaluated using univariate and multivariate Cox regression, also including information on age at diagnosis, tumor size, tumor grade, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status, proliferation index (Ki67) and molecular subtype, as well as an assessment of the presence of necrosis and inflammation in the tumor tissue. Univariate analysis showed that CRP, as a continuous variable, was significantly associated with DFS (P = 0.002, hazard ratio [HR] = 1.04, 95% confidence interval [CI] = 1.02-1.07) and OS (P = 0.036, HR= 1.03, 95% CI = 1.00-1.06), whereas a trend was observed for MFS (P = 0.111). In the multivariate analysis, CRP retained its significance for DFS (P = 0.033, HR= 1.01, 95% CI = 1.00-1.07) as well as OS (P = 0.023, HR= 1.03, 95% CI = 1.00-1.06), independent of established prognostic factors. Furthermore, large-scale gene expression analysis by Affymetrix HG-U133A arrays was performed for 72 (48.6%) patients. The correlations between serum CRP and gene expression levels in the corresponding carcinoma of the breast were assessed using Spearman's rank correlation, controlled for false-discovery rate. No significant correlation was observed between CRP level and gene expression indicative of an ongoing local inflammatory process. In summary, pre-operatively elevated CRP levels at the time of diagnosis were associated with shorter DFS and OS independent of established prognostic factors in node-negative breast cancer, supporting a possible link between inflammation and prognosis in breast cancer.

Indexed as

AdultAgedAged, 80 and overBreast NeoplasmsCell ProliferationCohort StudiesC-Reactive ProteinDisease-Free SurvivalErb-b2 Receptor Tyrosine KinasesFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGenome, HumanHumansInflammationKi-67 AntigenC-Reactive ProteinERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesKi-67 AntigenReceptors, EstrogenReceptors, Progesterone

Identifiers

PMID25340395
PMCPMC4207815
OpenAlexW2087259857

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.