Evidence map›Paper›PMID 25340337›Full record

Trial reportPloS one2014

A cluster randomised controlled effectiveness trial evaluating perinatal home visiting among South African mothers/infants.

Mary Jane Rotheram-Borus, Mark Tomlinson, Ingrid M le Roux, Jessica M Harwood, Scott Comulada, Mary J O'Connor, Robert E Weiss, Carol M Worthman

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00996528 (Neighborhood Alcohol & HIV Prevention in South African Townships), which is not on this map. Cited by 52 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 14 pooled it
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00996528 phase3unknown statusnot on this map

Neighborhood Alcohol & HIV Prevention in South African Townships (Philani)

TypeinterventionalSponsorUniversity of California, Los AngelesRan2007 to 2025Enrolled1,239ConditionsFetal Alcohol Syndrome, HIV, Nutrition DisordersArmsPhilani Intervention Program
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 14 syntheses or guidelines pooled it, 80 citations in OpenAlex.

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  6. Schedules for home visits in the early postpartum period.The Cochrane database of systematic reviews · 2021
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  18. Home Visiting and Antenatal Depression Affect the Quality of Mother and Child Interactions in South Africa.Journal of the American Academy of Child and Adolescent Psychiatry · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Mary Jane Rotheram-BorusDepartment of Psychiatry and Biobehavioral Medicine, Semel Institute, University of California Los Angeles, Los Angeles, California, United States of America.
Mark TomlinsonDepartment of Psychology, Stellenbosch University, Stellenbosch, South Africa.
Ingrid M le RouxPhilani Maternal, Child Health and Nutrition Programme, Elonwabeni, Cape Town, South Africa.
Jessica M HarwoodDepartment of Psychiatry and Biobehavioral Medicine, Semel Institute, University of California Los Angeles, Los Angeles, California, United States of America.
Scott ComuladaDepartment of Psychiatry and Biobehavioral Medicine, Semel Institute, University of California Los Angeles, Los Angeles, California, United States of America.
Mary J O'ConnorDepartment of Psychiatry and Biobehavioral Medicine, Semel Institute, University of California Los Angeles, Los Angeles, California, United States of America.
Robert E WeissDepartment of Biostatistics, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, California, United States of America.
Carol M WorthmanDepartment of Anthropology, Emory University, Atlanta, Georgia, United States of America.
University of California, Los Angeles · USEmory University · USStellenbosch University · ZA

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAPHAEL J LANDOVITZ · 1997 to 2026
$53.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANTON, PETER A · 1991 to 2018
$39.9M
Neighborhood Alcohol & HIV Prevention in South African TownshipsR01AA017104 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROTHERAM-BORUS, MARY JANE · 2007 to 2011
$3.8M
The Global Partnership for AIDS Behavioral Research: South Africa and U.S.R24AA022919 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROTHERAM-BORUS, MARY JANE · 2013 to 2017
$2.4M
NCATS NIH HHS UL1 TR000124NIAAA NIH HHS R01 AA017104NIAAA NIH HHS R24 AA022919NIAID NIH HHS P30 AI028697NIMH NIH HHS P30 MH058107NIMH NIH HHS P30 MH58107
6 · The paper itself

Abstract

backgroundInterventions are needed to reduce poor perinatal health. We trained community health workers (CHWs) as home visitors to address maternal/infant risks.

methodsIn a cluster randomised controlled trial in Cape Town townships, neighbourhoods were randomised within matched pairs to 1) the control, healthcare at clinics (n = 12 neighbourhoods; n = 594 women), or 2) a home visiting intervention by CBW trained in cognitive-behavioural strategies to address health risks (by the Philani Maternal, Child Health and Nutrition Programme), in addition to clinic care (n = 12 neighbourhoods; n = 644 women). Participants were assessed during pregnancy (2% refusal) and 92% were reassessed at two weeks post-birth, 88% at six months and 84% at 18 months later. We analysed 32 measures of maternal/infant well-being over the 18 month follow-up period using longitudinal random effects regressions. A binomial test for correlated outcomes evaluated overall effectiveness over time. The 18 month post-birth assessment outcomes also were examined alone and as a function of the number of home visits received.

resultsBenefits were found on 7 of 32 measures of outcomes, resulting in significant overall benefits for the intervention compared to the control when using the binomial test (p = 0.008); nevertheless, no effects were observed when only the 18 month outcomes were analyzed. Benefits on individual outcomes were related to the number of home visits received. Among women living with HIV, intervention mothers were more likely to implement the PMTCT regimens, use condoms during all sexual episodes (OR = 1.25; p = 0.014), have infants with healthy weight-for-age measurements (OR = 1.42; p = 0.045), height-for-age measurements (OR = 1.13, p<0.001), breastfeed exclusively for six months (OR = 3.59; p<0.001), and breastfeed longer (OR = 3.08; p<0.001). Number of visits was positively associated with infant birth weight ≥2500 grams (OR = 1.07; p = 0.012), healthy head-circumference-for-age measurements at 6 months (OR = 1.09, p = 0.017), and improved cognitive development at 18 months (OR = 1.02, p = 0.048).

conclusionsHome visits to neighbourhood mothers by CHWs may be a feasible strategy for enhancing maternal/child outcomes. However, visits likely must extend over several years for persistent benefits.

trial registrationClinicalTrials.gov NCT00996528.

Indexed as

House CallsMothersPostnatal CareFemaleHumansInfantOutcome Assessment, Health CarePregnancySouth Africa

Identifiers

PMID25340337
PMCPMC4207699
OpenAlexW2130808309

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.