ArticleJournal of renal injury prevention2013
AT2R -1332 G:A polymorphism and diabetic nephropathy in type 2 diabetes mellitus patients.
Article in Journal of renal injury prevention, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies.Journal of diabetes research · 2015Pooled it
- Serum Behavior of NT-3 and VEGFβ, Two Unstudied Growth Factors in Patients with Diabetes Mellitus and End-Stage Renal Disease.Journal of clinical medicine · 2025Article
- No Association of Angiotensin-Converting Enzyme Insertion/Deletion (ACE I/D) Gene Polymorphism in the Susceptibility to Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients: An Updated Meta-Analysis.Journal of personalized medicine · 2023Review
- Cutaneous manifestations in patients with end-stage renal disease on hemodialysis.Caspian journal of internal medicine · 2023Article
- Impact of exercise on renal function, oxidative stress, and systemic inflammation among patients with type 2 diabetic nephropathy.African health sciences · 2022Article
- Sonographic assessment of kidneys in patients with hypertension co-existed with diabetes mellitus and ischemic heart disease.Journal of family medicine and primary care · 2020Article
- Diabetes mellitus and renal failure: Prevention and management.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Review
- AT1R A1166C variants in patients with type 2 diabetes mellitus and diabetic nephropathy.Journal of nephropathology · 2015Article
- Antioxidant plants and diabetes mellitus.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Review
- Association of genetic variants with diabetic nephropathy.World journal of diabetes · 2014Review
- New concepts in nutraceuticals as alternative for pharmaceuticals.International journal of preventive medicine · 2014Review
- A systematic review of the role of renin angiotensin aldosterone system genes in diabetes mellitus, diabetic retinopathy and diabetic neuropathy.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Review
- Metformin and diabetic kidney disease: a mini-review on recent findings.Iranian journal of pediatrics · 2014Review
- Effect of vitamin D on insulin resistance and nephropathy in type 2 diabetes.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe rennin-angiotensin system (RAS) plays a central role in the regulation of sodium metabolism, vascular tone, blood pressure, renal hemodynamics, and vascular modeling and is activated by hyperglycemiaObjectives: In the present study the influence of AT2R -1332 G:A polymorphism on the risk of T2DM and its complications in a population from Western Iran has been investigated. PATIENTS AND
methodsIn a case-control study, 70 individuals with type 2 diabetes mellitus (T2DM) including normo-, micro- and macro-albuminuric patients and 112 healthy subjects from the Kermanshah province were studied to investigate the association between the angiotensin type 2 receptor (AT2R) -1332 G:A variants with the risk of T2DM and its complications. The genotypes of the AT2R were detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Analysis of AT2R -1332 G:A polymorphism indicated the absence of association between this polymorphism with T2DM and diabetic nephropathy.
resultsAnalysis of AT2R -1332 G:A polymorphism indicated the absence of association between this polymorphism with T2DM and diabetic nephropathy. In females with diabetic nephropathy a significantly higher frequency of AA genotype (50%) was detected compared to those without nephropathy (13.3%, p=0.015). The presence of A allele of AT2R was associated with significantly (p=0.029) increased risk of coronary artery disease (CAD) in diabetic patients without nephropathy.
conclusionOur study indicated an association between the AT2R -1332 G:A polymorphism and the risk of diabetic nephropathy in females only. Also, the A allele was associated with the risk of CAD in those diabetic patients without nephropathy.
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