ReviewFrontiers in bioengineering and biotechnology2014
Parts & pools: a framework for modular design of synthetic gene circuits.
Review in Frontiers in bioengineering and biotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Multiscale modelling of bioprocess dynamics and cellular growth.Microbial cell factories · 2024Article
- Design of Gene Boolean Gates and Circuits with Convergent Promoters.Methods in molecular biology (Clifton, N.J.) · 2023Article
- NOT Gates Based on Protein Degradation as a Case Study for a New Modular Modeling via SBML Level 3-Comp Package.Frontiers in bioengineering and biotechnology · 2022Article
- Review
- Design Automation in Synthetic Biology.Cold Spring Harbor perspectives in biology · 2017Review
- BioNetGen 2.2: advances in rule-based modeling.Bioinformatics (Oxford, England) · 2016Article
- Can terminators be used as insulators into yeast synthetic gene circuits?Journal of biological engineering · 2016Article
Corrections and comments
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Authors and funding
1 author.
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Abstract
Published in 2008, Parts & Pools represents one of the first attempts to conceptualize the modular design of bacterial synthetic gene circuits with Standard Biological Parts (DNA segments) and Pools of molecules referred to as common signal carriers (e.g., RNA polymerases and ribosomes). The original framework for modeling bacterial components and designing prokaryotic circuits evolved over the last years and brought, first, to the development of an algorithm for the automatic design of Boolean gene circuits. This is a remarkable achievement since gene digital circuits have a broad range of applications that goes from biosensors for health and environment care to computational devices. More recently, Parts & Pools was enabled to give a proper formal description of eukaryotic biological circuit components. This was possible by employing a rule-based modeling approach, a technique that permits a faithful calculation of all the species and reactions involved in complex systems such as eukaryotic cells and compartments. In this way, Parts & Pools is currently suitable for the visual and modular design of synthetic gene circuits in yeast and mammalian cells too.
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Registered trials
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