ReviewWorm2014
Nematode endogenous small RNA pathways.
Review in Worm, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Environmental sex determination in the cyst nematode Globodera pallida defaults to male development.BMC biology · 2026Article
- Dynamic Birth and Death of Argonaute Gene Family Functional Repertoire Across Caenorhabditis Nematodes.Genome biology and evolution · 2025Article
- Article
- Characterization of microRNAs in the cyst nematodeRNA biology · 2023Article
- piRNA pathway evolution beyond gonad context: Perspectives from apicomplexa and trypanosomatids.Frontiers in genetics · 2023Article
- Temperature-dependent Small RNA Expression Depends on Wild Genetic Backgrounds of Caenorhabditis briggsae.Molecular biology and evolution · 2022Article
- Small RNA pathways in the nematode Ascaris in the absence of piRNAs.Nature communications · 2022Article
- Intertissue small RNA communication mediates the acquisition and inheritance of hormesis in Caenorhabditis elegans.Communications biology · 2021Article
- In Vitro Acquisition of Specific Small Interfering RNAs Inhibits the Expression of Some Target Genes in the Plant EctoparasiteInternational journal of molecular sciences · 2019Article
- Non-Coding RNAs inMolecules and cells · 2019Review
- Caenorhabditis elegans as an emerging model system in environmental epigenetics.Environmental and molecular mutagenesis · 2018Review
- MicroRNAs of Toxocara canis and their predicted functional roles.Parasites & vectors · 2016Article
- The miRNA biogenesis in marine bivalves.PeerJ · 2016Article
- Discovery and characterization of the first non-coding RNA that regulates gene expression, micF RNA: A historical perspective.World journal of biological chemistry · 2015Article
- The soft genome.WormArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The discovery of small RNA silencing pathways has greatly extended our knowledge of gene regulation. Small RNAs have been presumed to play a role in every field of biology because they affect many biological processes via regulation of gene expression and chromatin remodeling. Most well-known examples of affected processes are development, fertility, and maintenance of genome stability. Here we review the role of the three main endogenous small RNA silencing pathways in Caenorhabditis elegans: microRNAs, endogenous small interfering RNAs, and PIWI-interacting RNAs. After providing an entry-level overview on how these pathways function, we discuss research on other nematode species providing insight into the evolution of these small RNA pathways. In understanding the differences between the endogenous small RNA pathways and their evolution, a more comprehensive picture is formed of the functions and effects of small RNAs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.