ArticleFrontiers in human neuroscience2014
Two Alzheimer's disease risk genes increase entorhinal cortex volume in young adults.
Article in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- The physiological effects of APOE genotype in healthy young/middle-aged individuals.Biological reviews of the Cambridge Philosophical Society · 2026Article
- Variation in Neurodegeneration-Linked Brain Regions in Young Adult APOE E4 Carriers With Spina Bifida.Annals of the Child Neurology Society · 2025Article
- APOE4 and age affect the brain entorhinal cortex structure and blood arachidonic acid and docosahexaenoic acid levels after mild TBI.Scientific reports · 2024Article
- Differences in Grey Matter Concentrations and Functional Connectivity between Young Carriers and Non-Carriers of the APOE ε4 Genotype.Journal of clinical medicine · 2024Article
- Genetic association between the APOE ε4 allele, toxicant exposures and Gulf war illness diagnosis.Environmental health : a global access science source · 2023Article
- Monitoring clusterin and fibrillar structures in aging and dementia.Aging brain · 2023Article
- APOE in the normal brain.Neurobiology of disease · 2020Review
- Genetic Burden for Late-Life Neurodegenerative Disease and Its Association With Early-Life Lipids, Brain, Behavior, and Cognition.Frontiers in psychiatry · 2020Article
- Female mice with apolipoprotein E4 domain interaction demonstrated impairments in spatial learning and memory performance and disruption of hippocampal cyto-architecture.Neurobiology of learning and memory · 2019Article
- Clusterin in Alzheimer's Disease: Mechanisms, Genetics, and Lessons From Other Pathologies.Frontiers in neuroscience · 2019Review
- APOE ε4 associated with preserved executive function performance and maintenance of temporal and cingulate brain volumes in younger adults.Brain imaging and behavior · 2017Article
- The Endosomal-Lysosomal Pathway Is Dysregulated byFrontiers in neuroscience · 2017Article
- Identification and modification of amyloid-independent phenotypes of APOE4 mice.Experimental neurology · 2016Article
- CFH Variants Affect Structural and Functional Brain Changes and Genetic Risk of Alzheimer's Disease.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Alzheimer's Disease Genetic Risk Factor APOE-ε4 Also Affects Normal Brain Function.Current Alzheimer research · 2016Review
- Genetically-mediated Grey and White Matter Alteration in Normal Elderly Individuals with the CLU-C Allele Gene.Current Alzheimer research · 2016Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Alzheimer's disease (AD) risk genes alter brain structure and function decades before disease onset. Apolipoprotein E (APOE) is the strongest known genetic risk factor for AD, and a related gene, apolipoprotein J (APOJ), also affects disease risk. However, the extent to which these genes affect brain structure in young adults remains unclear. Here, we report that AD risk alleles of these two genes, APOE-ε4 and APOJ-C, cumulatively alter brain volume in young adults. Using voxel-based morphometry (VBM) in 57 individuals, we examined the entorhinal cortex, one of the earliest brain regions affected in AD pathogenesis. Apolipoprotein E-ε4 carriers exhibited higher right entorhinal cortex volume compared to non-carriers. Interestingly, APOJ-C risk genotype was associated with higher bilateral entorhinal cortex volume in non-APOE-ε4 carriers. To determine the combined disease risk of APOE and APOJ status per subject, we used cumulative odds ratios as regressors for volumetric measurements. Higher disease risk corresponded to greater right entorhinal cortex volume. These results suggest that, years before disease onset, two key AD genetic risk factors may exert influence on the structure of a brain region where AD pathogenesis takes root.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.