Evidence map›Paper›PMID 25339866›Full record

ArticleFrontiers in cellular neuroscience2014

Methylene blue promotes quiescence of rat neural progenitor cells.

Luokun Xie, Gourav R Choudhury, Jixian Wang, Yong Park, Ran Liu, Fang Yuan, Chun-Li Zhang, Thomas Yorio, Kunlin Jin, Shao-Hua Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. HIV Tat Impairs Neurogenesis through Functioning As a Notch Ligand and Activation of Notch Signaling Pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Luokun XieDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center Fort Worth, TX, USA.
Gourav R ChoudhuryDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center Fort Worth, TX, USA.
Jixian WangDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center Fort Worth, TX, USA.
Yong ParkDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center Fort Worth, TX, USA.
Ran LiuDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center Fort Worth, TX, USA.
Fang YuanDepartment of Neurosurgery, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University Beijing, China.
Chun-Li ZhangDepartment of Molecular Biology, University of Texas Southwestern Medical Center Dallas, TX, USA.
Thomas YorioDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center Fort Worth, TX, USA.
Kunlin JinDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center Fort Worth, TX, USA.
Shao-Hua YangDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center Fort Worth, TX, USA ; Department of Neurosurgery, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University Beijing, China.
University of North Texas · USBeijing Institute of Neurosurgery · CNThe University of Texas Southwestern Medical Center · US

Funding

Aging and NeurogenesisR01AG021980 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JIN, KUNLIN · 2003 to 2014
$3.9M
Neuroglobin: cell metabolism and neuroprotectionR01NS088596 · NINDS · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI YANG, SHAOHUA · 2014 to 2018
$1.6M
NIA NIH HHS R01 AG021980NINDS NIH HHS R01 NS088596
6 · The paper itself

Abstract

Neural stem cell-based treatment holds a new therapeutic opportunity for neurodegenerative disorders. Here, we investigated the effect of methylene blue on proliferation and differentiation of rat neural progenitor cells (NPCs) both in vitro and in vivo. We found that methylene blue inhibited proliferation and promoted quiescence of NPCs in vitro without affecting committed neuronal differentiation. Consistently, intracerebroventricular infusion of methylene blue significantly inhibited NPC proliferation at the subventricular zone (SVZ). Methylene blue inhibited mTOR signaling along with down-regulation of cyclins in NPCs in vitro and in vivo. In summary, our study indicates that methylene blue may delay NPC senescence through enhancing NPCs quiescence.

Indexed as

methylene blueneural progenitor cellneurogenesisproliferationquiescence

Identifiers

PMID25339866
PMCPMC4188130
OpenAlexW2145247700

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.