Evidence map›Paper›PMID 25339800›Full record

ReviewWorld journal of gastroenterology2014

Irritable bowel syndrome: a microbiome-gut-brain axis disorder?

Paul J Kennedy, John F Cryan, Timothy G Dinan, Gerard Clarke

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

152 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Nutrients · 2019
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  15. Review
  16. Neuroglobin: A New Player in the Gut-Brain Axis.International journal of molecular sciences · 2026
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92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paul J KennedyPaul J Kennedy, Timothy G Dinan, Gerard Clarke, 1.15 Biosciences Institute, Department of Psychiatry, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland.
John F CryanPaul J Kennedy, Timothy G Dinan, Gerard Clarke, 1.15 Biosciences Institute, Department of Psychiatry, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland.
Timothy G DinanPaul J Kennedy, Timothy G Dinan, Gerard Clarke, 1.15 Biosciences Institute, Department of Psychiatry, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland.
Gerard ClarkePaul J Kennedy, Timothy G Dinan, Gerard Clarke, 1.15 Biosciences Institute, Department of Psychiatry, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irritable bowel syndrome (IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characterise the gut microbiota in IBS, they do confirm alterations in both community stability and diversity. Moreover, it has been reliably demonstrated that manipulation of the microbiota can influence the key symptoms, including abdominal pain and bowel habit, and other prominent features of IBS. A variety of strategies have been taken to study these interactions, including probiotics, antibiotics, faecal transplantations and the use of germ-free animals. There are clear mechanisms through which the microbiota can produce these effects, both humoral and neural. Taken together, these findings firmly establish the microbiota as a critical node in the gut-brain axis and one which is amenable to therapeutic interventions.

Indexed as

MicrobiotaAnimalsBrainCognitionHost-Pathogen InteractionsHumansIntestinesIrritable Bowel SyndromePain PerceptionPrognosisRisk FactorsStress, PsychologicalAbdominal painAnxietyCognitionGastrointestinal motilityIrritable bowel syndromeMicrobiomeTryptophan

Identifiers

PMID25339800
PMCPMC4202342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.