ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
In the blink of an eye: relating positive-feedback sensitivity to striatal dopamine D2-like receptors through blink rate.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 150 citations in OpenAlex.
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- Catecholaminergic Modulation of Semantic Processing in Sentence Comprehension.Cerebral cortex (New York, N.Y. : 1991) · 2020Trial
- Effects of meditation practice on spontaneous eyeblink rate.Psychophysiology · 2016Trial
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- Emergent blink rate in early childhood is associated with neural origins of executive function.Communications psychology · 2026Article
- Automatic neural mechanisms of social synchrony: pupil and Blink responses in adults with ADHD symptoms.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- The Role of Spontaneous Eye Blinks in Temporal Perception: An Eye Tracking Study.Journal of eye movement research · 2025Article
- Transcutaneous Vagus Nerve Stimulation Effects on Flavor-Evoked Electroencephalogram and Eye-Blink Rate.Brain and behavior · 2025Article
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- The influence of dopamine autoreceptors on temperament and addiction risk.Neuroscience and biobehavioral reviews · 2023Review
- Distinct Situational Cue Processing in Individuals with Kleptomania: A Preliminary Study.The international journal of neuropsychopharmacology · 2023Article
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- The Effects of Acute Virtual Reality Exergaming on Mood and Executive Function: Exploratory Crossover Trial.JMIR serious games · 2022Article
- Striatal D1 and D2 receptor availability are selectively associated with eye-blink rates after methylphenidate treatment.Communications biology · 2022Article
- A proxy measure of striatal dopamine predicts individual differences in temporal precision.Psychonomic bulletin & review · 2022Article
- Using Virtual Reality to Induce and Assess Objective Correlates of Nicotine Craving: Paradigm Development Study.JMIR serious games · 2022Article
- Maturation of Temporal Saccade Prediction from Childhood to Adulthood: Predictive Saccades, Reduced Pupil Size, and Blink Synchronization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Spontaneous Eye Blink Rate During the Working Memory Delay Period Predicts Task Accuracy.Frontiers in psychology · 2022Article
- Effects of stimulant medication on divergent and convergent thinking tasks related to creativity in adults with attention-deficit hyperactivity disorder.Psychopharmacology · 2021Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
For >30 years, positron emission tomography (PET) has proven to be a powerful approach for measuring aspects of dopaminergic transmission in the living human brain; this technique has revealed important relationships between dopamine D2-like receptors and dimensions of normal behavior, such as human impulsivity, and psychopathology, particularly behavioral addictions. Nevertheless, PET is an indirect estimate that lacks cellular and functional resolution and, in some cases, is not entirely pharmacologically specific. To identify the relationships between PET estimates of D2-like receptor availability and direct in vitro measures of receptor number, affinity, and function, we conducted neuroimaging and behavioral and molecular pharmacological assessments in a group of adult male vervet monkeys. Data gathered from these studies indicate that variation in D2-like receptor PET measurements is related to reversal-learning performance and sensitivity to positive feedback and is associated with in vitro estimates of the density of functional dopamine D2-like receptors. Furthermore, we report that a simple behavioral measure, eyeblink rate, reveals novel and crucial links between neuroimaging assessments and in vitro measures of dopamine D2 receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.