ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Short-term depression, temporal summation, and onset inhibition shape interval tuning in midbrain neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- A grapeful discovery: Reservoir computing with wine beads.PNAS nexus · 2025Article
- How auditory neurons count temporal intervals and decode information.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Collective sensing in electric fish.Nature · 2024Article
- Spike timing-dependent plasticity alters electrosensory neuron synaptic strength in vitro but does not consistently predict changes in sensory tuning in vivo.Journal of neurophysiology · 2023Article
- Neural network organization for courtship-song feature detection in Drosophila.Current biology : CB · 2022Article
- A small, computationally flexible network produces the phenotypic diversity of song recognition in crickets.eLife · 2021Article
- How auditory selectivity for sound timing arises: The diverse roles of GABAergic inhibition in shaping the excitation to interval-selective midbrain neurons.Progress in neurobiology · 2021Article
- Acoustic Pattern Recognition and Courtship Songs: Insights from Insects.Annual review of neuroscience · 2019Review
- Short-Term Synaptic Plasticity as a Mechanism for Sensory Timing.Trends in neurosciences · 2018Review
- Multisensory activation of ventral cochlear nucleus D-stellate cells modulates dorsal cochlear nucleus principal cell spatial coding.The Journal of physiology · 2018Article
- Review
- Phase-locking and bistability in neuronal networks with synaptic depression.Physica D. Nonlinear phenomena · 2018Article
- Functional roles of short-term synaptic plasticity with an emphasis on inhibition.Current opinion in neurobiology · 2017Review
- Behavioral and Single-Neuron Sensitivity to Millisecond Variations in Temporally Patterned Communication Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Phasic, suprathreshold excitation and sustained inhibition underlie neuronal selectivity for short-duration sounds.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Response recovery in the locust auditory pathway.Journal of neurophysiology · 2016Article
- Counting on dis-inhibition: a circuit motif for interval counting and selectivity in the anuran auditory system.Journal of neurophysiology · 2015Article
- Species-specificity of temporal processing in the auditory midbrain of gray treefrogs: interval-counting neurons.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Article
- Temporal integration at consecutive processing stages in the auditory pathway of the grasshopper.Journal of neurophysiology · 2015Article
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2 authors at 1 institution in 1 country.
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Abstract
A variety of synaptic mechanisms can contribute to single-neuron selectivity for temporal intervals in sensory stimuli. However, it remains unknown how these mechanisms interact to establish single-neuron sensitivity to temporal patterns of sensory stimulation in vivo. Here we address this question in a circuit that allows us to control the precise temporal patterns of synaptic input to interval-tuned neurons in behaviorally relevant ways. We obtained in vivo intracellular recordings under multiple levels of current clamp from midbrain neurons in the mormyrid weakly electric fish Brienomyrus brachyistius during stimulation with electrosensory pulse trains. To reveal the excitatory and inhibitory inputs onto interval-tuned neurons, we then estimated the synaptic conductances underlying responses. We found short-term depression in excitatory and inhibitory pathways onto all interval-tuned neurons. Short-interval selectivity was associated with excitation that depressed less than inhibition at short intervals, as well as temporally summating excitation. Long-interval selectivity was associated with long-lasting onset inhibition. We investigated tuning after separately nullifying the contributions of temporal summation and depression, and found the greatest diversity of interval selectivity among neurons when both mechanisms were at play. Furthermore, eliminating the effects of depression decreased sensitivity to directional changes in interval. These findings demonstrate that variation in depression and summation of excitation and inhibition helps to establish tuning to behaviorally relevant intervals in communication signals, and that depression contributes to neural coding of interval sequences. This work reveals for the first time how the interplay between short-term plasticity and temporal summation mediates the decoding of temporal sequences in awake, behaving animals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.