ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Sex and disease-related alterations of anterior insula functional connectivity in chronic abdominal pain.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 89 citations in OpenAlex.
- Effects of the antibiotic rifaximin on cortical functional connectivity are mediated through insular cortex.Scientific reports · 2021Trial
- Gender differences in functional connectivities between insular subdivisions and selective pain-related brain structures.The journal of headache and pain · 2018Trial
- Irritable bowel syndrome.Nature reviews. Disease primers · 2026Review
- Brain Changes Underlying Irritable Bowel Syndrome Symptom Improvement in Response to Mindfulness-Based Stress Reduction.Neurogastroenterology and motility · 2026Article
- Exploration of TCM Comprehensive Treatment of Irritable Bowel Syndrome Based on Pathophysiological Mechanism.International journal of general medicine · 2025Review
- Interoceptive Processing in Functional Gastrointestinal Disorders.International journal of molecular sciences · 2024Review
- Neuroplasticity of the white matter tracts underlying recovery of diarrhea-predominant irritable bowel syndrome following acupuncture treatment.Frontiers in neuroscience · 2024Article
- The neurobiology of irritable bowel syndrome.Molecular psychiatry · 2023Review
- Alterations in functional connectivity and interactions in resting-state networks in female patients with functional constipation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Structural and functional biomarkers of the insula subregions predict sex differences in aggression subscales.Human brain mapping · 2022Article
- Sex differences in pain along the neuraxis.Neuropharmacology · 2022Review
- Functional Neuroimaging in Irritable Bowel Syndrome: A Systematic Review Highlights Common Brain Alterations With Functional Movement Disorders.Journal of neurogastroenterology and motility · 2022Review
- Cerebral Metabolic Analysis of Patients With Colorectal Cancer and Chronic Enteritis: Inquiry Into Gut-Brain Crosstalk.Frontiers in neuroscience · 2022Article
- The Brain-Gut-Microbiome System: Pathways and Implications for Autism Spectrum Disorder.Nutrients · 2021Review
- Deep Brain Stimulation of the Posterior Insula in Chronic Pain: A Theoretical Framework.Brain sciences · 2021Review
- Sex- and Gender-Related Differences in Common Functional Gastroenterologic Disorders.Mayo Clinic proceedings · 2021Review
- An Investigation of Descending Pain Modulation in Women With Provoked Vestibulodynia: Alterations of Brain Connectivity.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Shared and Distinct Fractional Amplitude of Low-Frequency Fluctuation Patterns in Major Depressive Disorders With and Without Gastrointestinal Symptoms.Frontiers in psychiatry · 2021Article
- BNST-insula structural connectivity in humans.NeuroImage · 2020Article
- Unaltered Brain GABA Concentrations and Resting fMRI Activity in Functional Dyspepsia With and Without Comorbid Depression.Frontiers in psychiatry · 2020Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Resting-state functional magnetic resonance imaging has been used to investigate intrinsic brain connectivity in healthy subjects and patients with chronic pain. Sex-related differences in the frequency power distribution within the human insula (INS), a brain region involved in the integration of interoceptive, affective, and cognitive influences, have been reported. Here we aimed to test sex and disease-related alterations in the intrinsic functional connectivity of the dorsal anterior INS. The anterior INS is engaged during goal-directed tasks and modulates the default mode and executive control networks. By comparing functional connectivity of the dorsal anterior INS in age-matched female and male healthy subjects and patients with irritable bowel syndrome (IBS), a common chronic abdominal pain condition, we show evidence for sex and disease-related alterations in the functional connectivity of this region: (1) male patients compared with female patients had increased positive connectivity of the dorsal anterior INS bilaterally with the medial prefrontal cortex (PFC) and dorsal posterior INS; (2) female patients compared with male patients had greater negative connectivity of the left dorsal anterior INS with the left precuneus; (3) disease-related differences in the connectivity between the bilateral dorsal anterior INS and the dorsal medial PFC were observed in female subjects; and (4) clinical characteristics were significantly correlated to the insular connectivity with the dorsal medial PFC in male IBS subjects and with the precuneus in female IBS subjects. These findings are consistent with the INS playing an important role in modulating the intrinsic functional connectivity of major networks in the resting brain and show that this role is influenced by sex and diagnosis.
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