Evidence map›Paper›PMID 25339718›Full record

ArticleProceedings. Biological sciences2014

Evidence for a genetic basis of urogenital carcinoma in the wild California sea lion.

Helen M Browning, Karina Acevedo-Whitehouse, Frances M D Gulland, Ailsa J Hall, Jeanie Finlayson, Mark P Dagleish, Karen J Billington, Kathleen Colegrove, John A Hammond

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings. Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Pleural mesothelioma in a California sea lion (Zalophus californianus).The Journal of veterinary medical science · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Cancer in wildlife: patterns of emergence.Nature reviews. Cancer · 2018
    Review
  8. Genetic diversity, inbreeding and cancer.Proceedings. Biological sciences · 2018
    Review
  9. Article
  10. Article
  11. Common cancer in a wild animal: the California sea lion (Zalophus californianus) as an emerging model for carcinogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Helen M BrowningSea Mammal Research Unit, Scottish Oceans Institute, University of St Andrews, Fife, UK.
Karina Acevedo-WhitehouseUnit for Basic and Applied Microbiology, Autonomous University of Querétaro, Querétaro, Mexico.
Frances M D GullandThe Marine Mammal Center, Fort Cronkhite, Sausalito, CA, USA.
Ailsa J HallSea Mammal Research Unit, Scottish Oceans Institute, University of St Andrews, Fife, UK.
Jeanie FinlaysonThe Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, UK.
Mark P DagleishThe Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, UK.
Karen J BillingtonPirbright Laboratory, The Pirbright Institute, Surrey, UK.
Kathleen ColegroveZoological Pathology Program, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Maywood, IL, USA.
John A HammondPirbright Laboratory, The Pirbright Institute, Surrey, UK john.hammond@pirbright.ac.uk.
Moredun Research Institute · GBThe Pirbright Institute · GBUniversity of St Andrews · GBAutonomous University of Queretaro · MXMarine Mammal Center · USUniversity of Illinois Urbana-Champaign · US

Funding

Biotechnology and Biological Sciences Research Council BBS/E/I/00001410
6 · The paper itself

Abstract

Although neoplasia is a major cause of mortality in humans and domestic animals, it has rarely been described in wildlife species. One of the few examples is a highly prevalent urogenital carcinoma in California sea lions (CSLs). Although the aetiology of this carcinoma is clearly multifactorial, inbreeding depression, as estimated using levels of microsatellite multilocus heterozygosity, is identified as predictive for this neoplasia. On further analysis, this relationship appears to be largely driven by one marker, suggesting that a single locus might be associated with the occurrence of this disease in CSLs. In a case-control study, carcinoma was significantly associated with homozygosity at the Pv11 microsatellite locus. Pv11 was mapped to intron 9 of the heparanase 2 gene (HPSE2) locus, a very large gene encoding heparanase 2, which in humans is associated with multiple carcinomas. Correspondingly, immunohistochemical labelling in tissues was present in carcinoma cases within a single homozygous Pv11 genotype. To our knowledge, this is the first report of an individual locus being associated with cancer in any wildlife species. This adds emphasis to the study of HPSE2 in other species, including humans and will guide future studies on this sentinel species that shares much of its diet and environment with humans.

Indexed as

Genetic Predisposition to DiseaseAnimalsCarcinomaGenotypeGlucuronidaseInbreedingLoss of HeterozygosityMicrosatellite RepeatsOdds RatioSea LionsUrogenital NeoplasmsGlucuronidasecancerheparanase 2 geneodds ratiowildlife

Identifiers

PMID25339718
PMCPMC4213630
OpenAlexW2148121236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.