ArticleAmerican journal of physiology. Renal physiology2014
Somatomotor and sensory urethral control of micturition in female rats.
Article in American journal of physiology. Renal physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Animal models of spinal cord injury in neuro-urological research.Nature reviews. Urology · 2026Review
- Regenerative strategies for post-prostatectomy incontinence: stem cells, exosomes, and the path to clinical resolution.American journal of clinical and experimental urology · 2026Review
- UROREC: A cystometry and electromyography recording system for analyzing urinary incontinence parameters in rat models.PloS one · 2026Article
- A surgical and functional approach to the pelvic gross neuroanatomy of the female Yucatan minipig.Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft · 2025Article
- Contribution of pudendal nerve injury to stress urinary incontinence in a male rat model.Scientific reports · 2024Article
- Pathways and parameters of sacral neuromodulation in rats.American journal of physiology. Renal physiology · 2023Article
- Verification and Defined Dosage of Sodium Pentobarbital for a Urodynamic Study in the Possibility of Survival Experiments in Female Rat.BioMed research international · 2020Article
- Modulatory effects of intravesical P2X2/3 purinergic receptor inhibition on lower urinary tract electromyographic properties and voiding function of female rats with moderate or severe spinal cord injury.BJU international · 2019Article
- Electrical stimulation of the pudendal nerve promotes neuroregeneration and functional recovery from stress urinary incontinence in a rat model.American journal of physiology. Renal physiology · 2018Article
- Novel Neurostimulation of Autonomic Pelvic Nerves Overcomes Bladder-Sphincter Dyssynergia.Frontiers in neuroscience · 2018Article
- Electrical Activity of the Bladder Is Attenuated by Intravesical Inhibition of P2X2/3 Receptors During Micturition in Female Rats.International neurourology journal · 2017Article
- Effects of multiple simulated birth traumas on urethral continence function in rats.American journal of physiology. Renal physiology · 2017Article
- Neuroanatomic and behavioral correlates of urinary dysfunction induced by vaginal distension in rats.American journal of physiology. Renal physiology · 2016Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
In rats, axons of external urethral sphincter (EUS) motoneurons travel through the anastomotic branch of the pudendal nerve (ABPD) and anastomotic branch of the lumbosacral trunk (ABLT) and converge in the motor branch of the sacral plexus (MBSP). The aim of the present study was to determine in female rats the contribution of these somatomotor pathways and urethral sensory innervation from the dorsal nerve of the clitoris on urinary continence and voiding. EUS electromyographic (EMG) activity during cystometry, leak point pressure (LPP), and voiding efficiency (VE) were assessed in anesthetized virgin Sprague-Dawley female rats before and after transection of the above nerve branches. Transection of the MBSP eliminated EUS EMG, decreased LPP by 50%, and significantly reduced bladder contraction duration, peak pressure, intercontraction interval, and VE. Transection of the ABPD or ABLT decreased EUS EMG discharge and LPP by 25% but did not affect VE. Transection of the dorsal nerve of the clitoris did not affect LPP but reduced contraction duration, peak pressure, intercontraction interval, and VE. We conclude that somatomotor control of micturition is provided by the MBSP with axons travelling through the ABPD and ABLT. Partial somatomotor urethral denervation induces mild urinary incontinence, whereas partial afferent denervation induces voiding dysfunction. ABPD and ABLT pathways could represent a safeguard ensuring innervation to the EUS in case of upper nerve damage. Detailed knowledge of neuroanatomy and functional innervation of the urethra will enable more accurate animal models of neural development, disease, and dysfunction in the future.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.