ArticleBMC biology2014
Adaptation to prolonged neuromodulation in cortical cultures: an invariable return to network synchrony.
Article in BMC biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
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- Revealing and reshaping attractor dynamics in large networks of cortical neurons.PLoS computational biology · 2024Article
- A biophysical perspective on the resilience of neuronal excitability across timescales.Nature reviews. Neuroscience · 2023Review
- Synapse integrity and function: Dependence on protein synthesis and identification of potential failure points.Frontiers in molecular neuroscience · 2022Article
- Spontaneous and Perturbational Complexity in Cortical Cultures.Brain sciences · 2021Article
- Neuronal circuits overcome imbalance in excitation and inhibition by adjusting connection numbers.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Phosphorylation Hypothesis of Sleep.Frontiers in psychology · 2020Review
- A Biohybrid Setup for Coupling Biological and Neuromorphic Neural Networks.Frontiers in neuroscience · 2019Article
- In vitro Cortical Network Firing is Homeostatically Regulated: A Model for Sleep Regulation.Scientific reports · 2018Article
- Activity changes in neuron-astrocyte networks in culture under the effect of norepinephrine.PloS one · 2018Article
- Closed Loop Experiment Manager (CLEM)-An Open and Inexpensive Solution for Multichannel Electrophysiological Recordings and Closed Loop Experiments.Frontiers in neuroscience · 2017Article
- Mechanisms of Self-Sustained Oscillatory States in Hierarchical Modular Networks with Mixtures of Electrophysiological Cell Types.Frontiers in computational neuroscience · 2016Article
- Canalization of genetic and pharmacological perturbations in developing primary neuronal activity patterns.Neuropharmacology · 2016Article
- Perchance to dream? Primordial motor activity patterns in vertebrates from fish to mammals: their prenatal origin, postnatal persistence during sleep, and pathological reemergence during REM sleep behavior disorder.Neuroscience bulletin · 2015Review
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProlonged neuromodulatory regimes, such as those critically involved in promoting arousal and suppressing sleep-associated synchronous activity patterns, might be expected to trigger adaptation processes and, consequently, a decline in neuromodulator-driven effects. This possibility, however, has rarely been addressed.
resultsUsing networks of cultured cortical neurons, acetylcholine microinjections and a novel closed-loop 'synchrony-clamp' system, we found that acetylcholine pulses strongly suppressed network synchrony. Over the course of many hours, however, synchrony invariably reemerged, even when feedback was used to compensate for declining cholinergic efficacy. Network synchrony also reemerged following its initial suppression by noradrenaline, but this did not occlude the suppression of synchrony or its gradual reemergence following subsequent cholinergic input. Importantly, cholinergic efficacy could be restored and preserved over extended time scales by periodically withdrawing cholinergic input.
conclusionsThese findings indicate that the capacity of neuromodulators to suppress network synchrony is constrained by slow-acting, reactive processes. A multiplicity of neuromodulators and ultimately neuromodulator withdrawal periods might thus be necessary to cope with an inevitable reemergence of network synchrony.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.