ArticleJournal of clinical microbiology2015
Metagenomic analysis of viruses in feces from unsolved outbreaks of gastroenteritis in humans.
Article in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Diagnostic accuracy of metagenomic next-generation sequencing in diagnosing infectious diseases: a meta-analysis.Scientific reports · 2022Pooled it
- Integrating metagenomics and metatranscriptomics intoThe Journal of general virology · 2026Review
- Microbial Diversity in Children with Gastroenteritis in the Amazon Region of Brazil: Development and Validation of a Molecular Method for Complete Sequencing of Viral Genomes.Journal of genomics · 2024Article
- Occurrence of multiple respiratory viruses in wastewater in Queensland, Australia: Potential for community disease surveillance.The Science of the total environment · 2023Article
- Next Generation Sequencing Approaches to Characterize the Respiratory Tract Virome.Microorganisms · 2022Review
- Epidemiology of Human Adenovirus in Pakistani Children Hospitalized with Community-Acquired Gastroenteritis under the Age of Five Years.International journal of environmental research and public health · 2022Article
- Molecular Detection of Enteric Viruses in Under-Five Children with Diarrhea in Debre Tabor, Northwest Ethiopia.Infection and drug resistance · 2022Article
- Article
- Anti-influenza A virus activity of two Newtonia species and the isolated compound myricetin-3-o-rhamnoside.BMC complementary medicine and therapies · 2021Article
- Comparison of Nucleic Acid Extraction Methods for a Viral Metagenomics Analysis of Respiratory Viruses.Microorganisms · 2020Article
- Identification and molecular characterization of the first complete genome sequence of Human Parechovirus type 15.Scientific reports · 2020Article
- Analysis of viral diversity in stool samples from infants and children with acute gastroenteritis in Kuwait using Metagenomics approach.Virology journal · 2020Article
- Genomic constellation of human Rotavirus A strains identified in Northern Brazil: a 6-year follow-up (2010-2016).Revista do Instituto de Medicina Tropical de Sao Paulo · 2020Article
- Foodborne viruses: Detection, risk assessment, and control options in food processing.International journal of food microbiology · 2018Review
- Pepper mild mottle virus: A plant pathogen with a greater purpose in (waste)water treatment development and public health management.Water research · 2018Review
- Metagenomic analysis of viral diversity in respiratory samples from patients with respiratory tract infections in Kuwait.Journal of medical virology · 2018Article
- Article
- Optimization and validation of sample preparation for metagenomic sequencing of viruses in clinical samples.Microbiome · 2017Article
- Translational metagenomics and the human resistome: confronting the menace of the new millennium.Journal of molecular medicine (Berlin, Germany) · 2017Review
- Metagenomics: The Next Culture-Independent Game Changer.Frontiers in microbiology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The etiology of an outbreak of gastroenteritis in humans cannot always be determined, and ∼25% of outbreaks remain unsolved in New Zealand. It is hypothesized that novel viruses may account for a proportion of unsolved cases, and new unbiased high-throughput sequencing methods hold promise for their detection. Analysis of the fecal metagenome can reveal the presence of viruses, bacteria, and parasites which may have evaded routine diagnostic testing. Thirty-one fecal samples from 26 gastroenteritis outbreaks of unknown etiology occurring in New Zealand between 2011 and 2012 were selected for de novo metagenomic analysis. A total data set of 193 million sequence reads of 150 bp in length was produced on an Illumina MiSeq. The metagenomic data set was searched for virus and parasite sequences, with no evidence of novel pathogens found. Eight viruses and one parasite were detected, each already known to be associated with gastroenteritis, including adenovirus, rotavirus, sapovirus, and Dientamoeba fragilis. In addition, we also describe the first detection of human parechovirus 3 (HPeV3) in Australasia. Metagenomics may thus provide a useful audit tool when applied retrospectively to determine where routine diagnostic processes may have failed to detect a pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.