Trial reportThe journal of headache and pain2014
Nutrition intervention for migraine: a randomized crossover trial.
Trial report in The journal of headache and pain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 34 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Nutritional Intervention for Migraines
A Nutritional Intervention for Migraines-2
Who cites it
34 citing papers in PubMed, 6 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Impact of Dietary Patterns on Migraine Management: Mechanisms of Action and Recent Literature Insights.Brain and behavior · 2025Pooled it
- Vegetarian or vegan diets and blood lipids: a meta-analysis of randomized trials.European heart journal · 2023Pooled it
- The Role of Diet and Nutrition in Migraine Triggers and Treatment: A Systematic Literature Review.Headache · 2020Pooled it
- Effects of Surgical and Non-surgical Weight Loss on Migraine Headache: a Systematic Review and Meta-Analysis.Obesity surgery · 2020Pooled it
- The effects of plant-based diets on the body and the brain: a systematic review.Translational psychiatry · 2019Pooled it
- Association between plant-based diets and plasma lipids: a systematic review and meta-analysis.Nutrition reviews · 2017Pooled it
- Addressing Pain Using a Mediterranean Ketogenic Nutrition Program in Older Adults with Mild Cognitive Impairment.Journal of pain research · 2024Trial
- Dietary Modulation of Migraine: Metabolic, Neuroinflammatory and Microbiota-Mediated Mechanisms.Journal of clinical medicine · 2026Review
- A Plant-Based Food Guide Adapted for Low-Fat Diets: The VegPlate Low-Fat (VP_LF).Foods (Basel, Switzerland) · 2024Article
- The Impact of Food Specific IgG Antibodies on Migraine and Its Comorbidities.Immunity, inflammation and disease · 2024Article
- The Evidence for Diet as a Treatment in Migraine-A Review.Nutrients · 2024Review
- Healthy eating index 2015 might be associated with migraine headaches: Results from a Case-Control study.Food science & nutrition · 2024Article
- Unraveling the MSG-Headache Controversy: an Updated Literature Review.Current pain and headache reports · 2024Review
- Associations between dietary diversity score and migraine headaches: the results from a cross-sectional study.Frontiers in nutrition · 2023Article
- Is there an association between a plant-based eating pattern and clinical findings of a migraine headache?Frontiers in nutrition · 2023Article
- Article
- Article
- What makes a plant-based diet? a review of current concepts and proposal for a standardized plant-based dietary intervention checklist.European journal of clinical nutrition · 2022Review
- A Digital Health Application Allowing a Personalized Low-Glycemic Nutrition for the Prophylaxis of Migraine: Proof-of-Concept Data from a Retrospective Cohort Study.Journal of clinical medicine · 2022Article
- Association between sleep quality, migraine and migraine burden.Frontiers in neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLimited evidence suggests that dietary interventions may offer a promising approach for migraine. The purpose of this study was to determine the effects of a low-fat plant-based diet intervention on migraine severity and frequency.
methodsForty-two adult migraine sufferers were recruited from the general community in Washington, DC, and divided randomly into two groups. This 36-week crossover study included two treatments: dietary instruction and placebo supplement. Each treatment period was 16 weeks, with a 4-week washout between. During the diet period, a low-fat vegan diet was prescribed for 4 weeks, after which an elimination diet was used. Participants were assessed at the beginning, midpoint, and end of each period. Significance was determined using student's t-tests.
resultsWorst headache pain in last 2 weeks, as measured by visual analog scale, was initially 6.4/10 cm (SD 2.1 cm), and declined 2.1 cm during the diet period and 0.7 cm during the supplement period (p=0.03). Average headache intensity (0-10 scale) was initially 4.2 (SD 1.4) per week, and this declined by 1.0 during the diet period and by 0.5 during the supplement period (p=0.20). Average headache frequency was initially 2.3 (SD 1.8) per week, and this declined by 0.3 during the diet period and by 0.4 during the supplement period (p=0.61). The Patient's Global Impression of Change showed greater improvement in pain during the diet period (p<0.001).
conclusionsThese results suggest that a nutritional approach may be a useful part of migraine treatment, but that methodologic issues necessitate further research.
trial registrationClinicaltrials.gov, NCT01699009 and NCT01547494.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.