ReviewJournal of human hypertension2015
Pathogenesis of obstructive sleep apnoea in hypertensive patients: role of fluid retention and nocturnal rostral fluid shift.
Review in Journal of human hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Effect of dapagliflozin on obstructive sleep apnea in patients with type 2 diabetes: a preliminary study.Nutrition & diabetes · 2019Trial
- Use of the biopsychosocial model of functioning in physiotherapeutic evaluation of patients with obstructive sleep apnea: a survey-based study.Sleep & breathing = Schlaf & Atmung · 2025Article
- Relationship between body roundness index and obstructive sleep apnea: a population-based study.Frontiers in nutrition · 2025Article
- Sleep quality and risk of obstructive sleep apnea among breast cancer survivors with and without lymphedema.Sleep & breathing = Schlaf & Atmung · 2024Article
- Associations between air pollution, intracellular-to-extracellular water distribution, and obstructive sleep apnea manifestations.Frontiers in public health · 2023Article
- Screening for Obstructive Sleep Apnea Risk by Using Machine Learning Approaches and Anthropometric Features.Sensors (Basel, Switzerland) · 2022Article
- Coexistence of Moderate-to-Severe Obstructive Sleep Apnea and Inflammation Accelerates the Risk of Progression of Arterial Stiffness: A Prospective 6-Year Study.Life (Basel, Switzerland) · 2022Article
- Effect of antihypertensive medications on sleep status in hypertensive patients.Sleep and biological rhythms · 2022Article
- Obstructive sleep apnea and ambulatory blood pressure monitoring: current evidence and research gaps.Journal of human hypertension · 2021Review
- Sitting Less and Moving More: Implications for Hypertension.Hypertension (Dallas, Tex. : 1979) · 2018Review
- Impact of concomitant medications on obstructive sleep apnoea.British journal of clinical pharmacology · 2017Review
- Chronic Kidney Disease and Sleeping Disordered Breathing (SDB).Current hypertension reviews · 2016Review
- Is Mixed Apnea Associated with Non-Rapid Eye Movement Sleep a Reversible Compensatory Sign of Heart Failure?The American journal of case reports · 2015Article
- Response to 'A retrospective review of sleep disordered breathing, hypertension and cardiovascular diseases in spinal cord injury patients'.Spinal cord · 2015Article
- Article
- How obesity affects nasal function in obstructive sleep apnea: anatomic and volumetric parameters.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obstructive sleep apnoea (OSA) is highly prevalent in hypertensive patients, particularly those with drug resistance. Evidence from animal experiments, epidemiologic studies and clinical trials strongly suggest a causal link. Mechanistic studies argue for increased sympathetic neural activity and endothelial dysfunction. However, disturbances in fluid volume regulation and distribution may also be involved in the pathogenesis of these two conditions. Several studies have shown a high prevalence of OSA in fluid-retaining states including hypertension, a direct relationship between the severity of OSA and the volume of fluid displaced from the legs to the neck during sleep, and a decrease in upper airway cross-sectional area in response to graded lower body positive pressure. Treatments targeting fluid retention and redistribution, including diuretics, mineralocorticoid antagonists, exercise, and possibly renal denervation lower blood pressure and reduce the apnoea-hypopnoea index, a measure of OSA severity. From these observations, it has been postulated that during the daytime, excess fluid collects in the lower extremities due to gravity, and on lying down overnight is redistributed rostrally to the neck, where it may narrow the upper airway and increase its collapsibility, predisposing to OSA when pharyngeal dilator muscle activity decreases during sleep. This article discusses the associations between OSA and hypertension and reviews the evidence for fluid accumulation and its nocturnal rostral redistribution in the pathogenesis of OSA in hypertensive patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.