ArticleJournal of human hypertension2015
Blood pressure response to renal nerve stimulation in patients undergoing renal denervation: a feasibility study.
Article in Journal of human hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05421767 (National Tawan University Hospital), which is not on this map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
National Tawan University Hospital
Who cites it
35 citing papers in PubMed.
- Reframing renal denervation: from blood pressure reduction to autonomic disease modification-a state-of-the-art review.Clinical hypertension · 2026Review
- Renal nerve stimulation modulates renal blood flow in a frequency-dependent manner.Bioelectronic medicine · 2025Article
- Renal nerve stimulation modulates renal blood flow in a frequency-dependent manner.Research square · 2025Article
- Effects of renal denervation at BP-elevation/reduction sites guided by renal nerve stimulation on atrial neural and structural remodeling in a hypertensive canine model.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Differences in the effectiveness and safety of different renal denervation devices.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Complex Hemodynamic Responses to Trans-Vascular Electrical Stimulation of the Renal Nerve in Anesthetized Pigs.IEEE open journal of engineering in medicine and biology · 2024Article
- Current problems in renal denervation and a hope to break the stage.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- Renal Denervation as a Complementary Treatment Option for Uncontrolled Arterial Hypertension: A Situation Assessment.Journal of clinical medicine · 2023Review
- Renal nerve stimulation identifies renal innervation and optimizes the strategy for renal denervation in canine.Journal of translational medicine · 2023Article
- The role of renal nerve stimulation in percutaneous renal denervation for hypertension: A mini-review.Journal of clinical hypertension (Greenwich, Conn.) · 2022Review
- Mapping Renal Innervations by Renal Nerve Stimulation and Characterizations of Blood Pressure Response Patterns.Journal of cardiovascular translational research · 2022Article
- Present Evidence of Determinants to Predict the Efficacy of Renal Denervation.International journal of hypertension · 2022Review
- Quantitative analysis of renal arterial variations affecting the eligibility of catheter-based renal denervation using multi-detector computed tomography angiography.Scientific reports · 2020Article
- Device-based therapies for arterial hypertension.Nature reviews. Cardiology · 2020Review
- Proceedings from the 3rd European Clinical Consensus Conference for clinical trials in device-based hypertension therapies.European heart journal · 2020Article
- Renal Denervation in Asia: Consensus Statement of the Asia Renal Denervation Consortium.Hypertension (Dallas, Tex. : 1979) · 2020Review
- Selective renal denervation guided by renal nerve stimulation: mapping renal nerves for unmet clinical needs.Journal of human hypertension · 2019Article
- Neuromodulation for the Treatment of Heart Rhythm Disorders.JACC. Basic to translational science · 2019Review
- Renal sympathetic denervation induces changes in heart rate variability and is associated with a lower sympathetic tone.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
- Changes in arterial pressure hemodynamics in response to renal nerve stimulation both before and after renal denervation.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During renal sympathetic denervation (RDN), no mapping of renal nerves is performed and there is no clear end point of RDN. We hypothesized high-frequency renal nerve stimulation (RNS) may increase blood pressure (BP), and this increase is significantly blunted after RDN. The aim of this study was to determine the feasibility of RNS in patients undergoing RDN. Eight patients with resistant hypertension undergoing RDN were included. A quadripolar catheter was positioned at four different sites in either renal artery. RNS was performed during 1 min with a pacing frequency of 20 Hz. After all patients successfully underwent RDN, RNS was repeated at the site of maximum BP response before RDN in either renal artery. Mean age was 66 years. During RNS, BP increased significantly from 108/55 to 132/68 mm Hg (P < 0.001). After RDN, systolic BP response at the site of maximum response to RNS was significantly blunted (+43.1 vs +9.3 mm Hg, P = 0.002). In three patients, a systolic BP increase >10 mm Hg was observed after RDN. In conclusion, RNS resulted in an acute temporary BP increase. This response was significantly blunted after RDN. RNS may potentially serve as an end point for RDN.
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