Observational studyAmerican journal of reproductive immunology (New York, N.Y. : 1989)2015
Impact of CD4+ lymphocytes and HIV infection on Anti-Müllerian Hormone levels in a large cohort of HIV-infected and HIV-uninfected women.
Observational study in American journal of reproductive immunology (New York, N.Y. : 1989), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Correlates and Timing of Reproductive Aging Transitions in a Global Cohort of Midlife Women With Human Immunodeficiency Virus: Insights From the REPRIEVE Trial.The Journal of infectious diseases · 2020 · on this mapTrial
- Comprehensive Assessment of Genital Infections and Reproductive Health in Women Visiting a Fertility Clinic in Warangal, India-A Case-Control Study.Health science reports · 2025Article
- Primary ovarian insufficiency: update on clinical and genetic findings.Frontiers in endocrinology · 2024Review
- Ovarian Reserve Disorders, Can We Prevent Them? A Review.International journal of molecular sciences · 2022Review
- Cardiovascular disease risk in women living with HIV.Current opinion in HIV and AIDS · 2022Review
- Menopause care in women living with HIV in the UK - A review.Journal of virus eradication · 2022Review
- The alterations of circulating mucosal-associated invariant T cells in polycystic ovary syndrome.Frontiers in endocrinology · 2022Article
- Prevalence of Gynecological Related Symptoms and Quality of Life in Women Living with HIV/AIDS: a Secondary Analysis from an Online, Cross-Sectional Survey in China.International journal of women's health · 2022Article
- Greater Sensorimotor Deficits and Abnormally Lower Globus Pallidus Fractional Anisotropy in HIV+ Women than in HIV+ Men.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021Article
- Factors associated with worse cerebrovascular function in aging women with and at risk for HIV.AIDS (London, England) · 2021Article
- HIV-1 Tat promotes age-related cognitive, anxiety-like, and antinociceptive impairments in female mice that are moderated by aging and endocrine status.GeroScience · 2021Article
- Intramyocardial Triglycerides Among Women With vs Without HIV: Hormonal Correlates and Functional Consequences.The Journal of clinical endocrinology and metabolism · 2019Article
- Conceptualizing the Risks of Coronary Heart Disease and Heart Failure Among People Aging with HIV: Sex-Specific Considerations.Current treatment options in cardiovascular medicine · 2019Review
- Prolonged Amenorrhea and Resumption of Menses in Women with HIV.Journal of women's health (2002) · 2018Article
- In people living with HIV (PLWH), menopause (natural or surgical) contributes to the greater symptom burden in women: results from an online US survey.Menopause (New York, N.Y.) · 2018Article
- Anti-müllerian hormone levels are reduced in women living with human immunodeficiency virus compared to control women: a case-control study from Copenhagen, Denmark.Journal of virus eradication · 2018Article
- Sex Differences in Select Non-communicable HIV-Associated Comorbidities: Exploring the Role of Systemic Immune Activation/Inflammation.Current HIV/AIDS reports · 2017Review
- Cardiovascular disease risk among women living with HIV in North America and Europe.Current opinion in HIV and AIDS · 2017Review
- Use of antimüllerian hormone to predict the menopausal transition in HIV-infected women.American journal of obstetrics and gynecology · 2017Observational
- The menopause transition in women living with HIV: current evidence and future avenues of research.Journal of virus eradication · 2016Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 1 country.
Funding
Abstract
problemEffects of HIV infection on ovarian function and aging are unclear. METHOD OF STUDY: Anti-Müllerian Hormone (AMH) levels were analyzed in 2621 HIV-infected and 941 uninfected participants using left-censored longitudinal models.
resultsAge-adjusted AMH levels were 16% lower in women with undetectable viraemia and 26% lower in detectable viraemia, relative to uninfected women. Current CD4 count associated with higher AMH in both HIV-infected and HIV-uninfected women. After controlling for current and nadir CD4, AMH was ~15% higher in HIV-infected relative to uninfected women, regardless of HIV viraemia. Gravidity, amenorrhea, and nadir total lymphocyte counts associated with higher AMH; hormonal contraceptive use and past weight loss associated with lower AMH.
conclusionsCD4 + lymphocyte counts were associated with AMH in both HIV-infected and uninfected women. After adjustment for CD4 counts and age, HIV infection was associated with higher AMH. CD4 T cells and cellular activation may influence ovarian granulosa cell function.
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