SynthesisBMC cancer2014
Increased incidence of head and neck cancer in liver transplant recipients: a meta-analysis.
Synthesis in BMC cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Oral diseases after liver transplantation: a systematic review and meta-analysis.British dental journal · 2021Pooled it
- Surveillance ofFrontiers in oncology · 2025Article
- Reconstructive Surgery of the Head and Neck in Organ Transplant Recipients: A Case Report and a Review of the Literature.Journal of clinical medicine · 2024Review
- Precision and Immunoprevention Strategies for Tobacco-Related Head and Neck Cancer Chemoprevention.Current treatment options in oncology · 2021Review
- Article
- Head and neck squamous cell carcinoma in solid organ transplant recipients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Current Challenges in the Post-Transplant Care of Liver Transplant Recipients in Germany.Journal of clinical medicine · 2020Article
- Article
- No significant association between immunosuppression in solid organ transplantation and prostate cancer risk: a meta-analysis of cohort studies.Translational cancer research · 2019Article
- Epidemiology of Head and Neck Squamous Cell Carcinomas: Impact on Staging and Prevention Strategies.Current treatment options in oncology · 2019Review
- T cell receptor repertoire usage in cancer as a surrogate marker for immune responses.Seminars in immunopathology · 2017Review
- Incidence, risk factors and outcomes of de novo malignancies post liver transplantation.World journal of hepatology · 2016Review
- An Ecological Study of the Association between Opiate Use and Incidence of Cancers.Addiction & health · 2016Article
- Association of Head and Neck Cancers in Chronic Osteomyelitis: A National Retrospective Cohort Study.Medicine · 2016Article
- Dental and ENT Evaluation Before Liver Transplantation.Journal of clinical and experimental hepatologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is unclear whether liver transplantation is associated with an increased incidence of post-transplant head and neck cancer. This comprehensive meta-analysis evaluated the association between liver transplantation and the risk of head and neck cancer using data from all available studies.
methodsPubMed and Web of Science were systematically searched to identify all relevant publications up to March 2014. Standardized incidence ratio (SIR) and 95% confidence intervals (CIs) for risk of head and neck cancer in liver transplant recipients were calculated. Tests for heterogeneity, sensitivity, and publishing bias were also performed.
resultOf the 964 identified articles, 10 were deemed eligible. These studies included data on 56,507 patients with a total follow-up of 129,448.9 patient-years. SIR for head and neck cancer was 3.836-fold higher (95% CI 2.754-4.918, P = 0.000) in liver transplant recipients than in the general population. No heterogeneity or publication bias was observed. Sensitivity analysis indicated that omission of any of the studies resulted in an SIR for head and neck cancer between 3.488 (95% CI: 2.379-4.598) and 4.306 (95% CI: 3.020-5.592).
conclusionsLiver transplant recipients are at higher risk of developing head and neck cancer than the general population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.