Evidence map›Paper›PMID 25338633›Full record

ArticleSocial cognitive and affective neuroscience2015

Neural and genetic markers of vulnerability to post-traumatic stress symptoms among survivors of the World Trade Center attacks.

Andreas Olsson, Ethan Kross, Samuel S Nordberg, Anna Weinberg, Jochen Weber, Sonja Schmer-Galunder, John Fossella, Tor D Wager, George A Bonanno, Kevin N Ochsner

Abstract read
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In one paragraph

Article in Social cognitive and affective neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andreas OlssonDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden, Department of Psychology, University of Michigan, Ann Arbor, MI, USA, Department of Psychology, Pennsylvania State University, University Park, USA, Department of Psychology, State University of New York, Stony Brook, USA, Department of Psychology, Columbia University, New York, USA, Smart Information Flow Technologies, Minneapolis, MN, USA, Sackler Institute for Developmental Psychobiology, Weill Medical College, Cornell University, Cornell, USA, Department of Psychology and Neuroscience and the Institute for Cognitive Science, University of Colorado, Boulder, CO, USA, and Teachers College, Columbia University, New York, USA Andreas.Olsson@ki.se.
Ethan KrossDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden, Department of Psychology, University of Michigan, Ann Arbor, MI, USA, Department of Psychology, Pennsylvania State University, University Park, USA, Department of Psychology, State University of New York, Stony Brook, USA, Department of Psychology, Columbia University, New York, USA, Smart Information Flow Technologies, Minneapolis, MN, USA, Sackler Institute for Developmental Psychobiology, Weill Medical College, Cornell University, Cornell, USA, Department of Psychology and Neuroscience and the Institute for Cognitive Science, University of Colorado, Boulder, CO, USA, and Teachers College, Columbia University, New York, USA.
Samuel S NordbergDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden, Department of Psychology, University of Michigan, Ann Arbor, MI, USA, Department of Psychology, Pennsylvania State University, University Park, USA, Department of Psychology, State University of New York, Stony Brook, USA, Department of Psychology, Columbia University, New York, USA, Smart Information Flow Technologies, Minneapolis, MN, USA, Sackler Institute for Developmental Psychobiology, Weill Medical College, Cornell University, Cornell, USA, Department of Psychology and Neuroscience and the Institute for Cognitive Science, University of Colorado, Boulder, CO, USA, and Teachers College, Columbia University, New York, USA.
Anna WeinbergDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden, Department of Psychology, University of Michigan, Ann Arbor, MI, USA, Department of Psychology, Pennsylvania State University, University Park, USA, Department of Psychology, State University of New York, Stony Brook, USA, Department of Psychology, Columbia University, New York, USA, Smart Information Flow Technologies, Minneapolis, MN, USA, Sackler Institute for Developmental Psychobiology, Weill Medical College, Cornell University, Cornell, USA, Department of Psychology and Neuroscience and the Institute for Cognitive Science, University of Colorado, Boulder, CO, USA, and Teachers College, Columbia University, New York, USA.
Jochen WeberDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden, Department of Psychology, University of Michigan, Ann Arbor, MI, USA, Department of Psychology, Pennsylvania State University, University Park, USA, Department of Psychology, State University of New York, Stony Brook, USA, Department of Psychology, Columbia University, New York, USA, Smart Information Flow Technologies, Minneapolis, MN, USA, Sackler Institute for Developmental Psychobiology, Weill Medical College, Cornell University, Cornell, USA, Department of Psychology and Neuroscience and the Institute for Cognitive Science, University of Colorado, Boulder, CO, USA, and Teachers College, Columbia University, New York, USA.
Sonja Schmer-GalunderDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden, Department of Psychology, University of Michigan, Ann Arbor, MI, USA, Department of Psychology, Pennsylvania State University, University Park, USA, Department of Psychology, State University of New York, Stony Brook, USA, Department of Psychology, Columbia University, New York, USA, Smart Information Flow Technologies, Minneapolis, MN, USA, Sackler Institute for Developmental Psychobiology, Weill Medical College, Cornell University, Cornell, USA, Department of Psychology and Neuroscience and the Institute for Cognitive Science, University of Colorado, Boulder, CO, USA, and Teachers College, Columbia University, New York, USA.
John FossellaDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden, Department of Psychology, University of Michigan, Ann Arbor, MI, USA, Department of Psychology, Pennsylvania State University, University Park, USA, Department of Psychology, State University of New York, Stony Brook, USA, Department of Psychology, Columbia University, New York, USA, Smart Information Flow Technologies, Minneapolis, MN, USA, Sackler Institute for Developmental Psychobiology, Weill Medical College, Cornell University, Cornell, USA, Department of Psychology and Neuroscience and the Institute for Cognitive Science, University of Colorado, Boulder, CO, USA, and Teachers College, Columbia University, New York, USA.
Tor D WagerDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden, Department of Psychology, University of Michigan, Ann Arbor, MI, USA, Department of Psychology, Pennsylvania State University, University Park, USA, Department of Psychology, State University of New York, Stony Brook, USA, Department of Psychology, Columbia University, New York, USA, Smart Information Flow Technologies, Minneapolis, MN, USA, Sackler Institute for Developmental Psychobiology, Weill Medical College, Cornell University, Cornell, USA, Department of Psychology and Neuroscience and the Institute for Cognitive Science, University of Colorado, Boulder, CO, USA, and Teachers College, Columbia University, New York, USA.
George A BonannoDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden, Department of Psychology, University of Michigan, Ann Arbor, MI, USA, Department of Psychology, Pennsylvania State University, University Park, USA, Department of Psychology, State University of New York, Stony Brook, USA, Department of Psychology, Columbia University, New York, USA, Smart Information Flow Technologies, Minneapolis, MN, USA, Sackler Institute for Developmental Psychobiology, Weill Medical College, Cornell University, Cornell, USA, Department of Psychology and Neuroscience and the Institute for Cognitive Science, University of Colorado, Boulder, CO, USA, and Teachers College, Columbia University, New York, USA.
Kevin N OchsnerDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden, Department of Psychology, University of Michigan, Ann Arbor, MI, USA, Department of Psychology, Pennsylvania State University, University Park, USA, Department of Psychology, State University of New York, Stony Brook, USA, Department of Psychology, Columbia University, New York, USA, Smart Information Flow Technologies, Minneapolis, MN, USA, Sackler Institute for Developmental Psychobiology, Weill Medical College, Cornell University, Cornell, USA, Department of Psychology and Neuroscience and the Institute for Cognitive Science, University of Colorado, Boulder, CO, USA, and Teachers College, Columbia University, New York, USA.

Funding

X-RAY COMPATIBLE RF-COIL FOR MR IMAGINGP41RR009784 · NCRR · STANFORD UNIVERSITY · PI GLOVER, GARY H · 1995 to 2011
$15.0M
The Neural Bases of the Cognitive Control of EmotionR01MH076137 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI OCHSNER, KEVIN N · 2006 to 2010
$1.8M
NCRR NIH HHS P41 RR009784NIMH NIH HHS MH076137NIMH NIH HHS R01 MH076137
6 · The paper itself

Abstract

Although recent research has begun to describe the neural and genetic processes underlying variability in responses to trauma, less is known about how these processes interact. We addressed this issue by using functional magnetic resonance imaging to examine the relationship between posttraumatic stress symptomatology (PTSS), a common genetic polymorphism of the serotonin transporter [5-HTT (5-hydroxy tryptamine)] gene and neural activity in response to viewing images associated with the 9/11 terrorist attack among a rare sample of high-exposure 9/11 survivors (n = 17). Participants varied in whether they carried a copy of the short allele in the promoter region of the 5-HTT gene. During scanning, participants viewed images of the 9/11 attack, non-9/11 negative and neutral images. Three key findings are reported. First, carriers of the short allele displayed higher levels of PTSS. Second, both PTSS and the presence of the short allele correlated negatively with activity in a network of cortical midline regions (e.g. the retrosplenal and more posterior cingulate cortices (PCCs)) implicated in episodic memories and self-reflection when viewing 9/11 vs non-9/11 negative control images. Finally, exploratory analyses indicated that PCC activity mediated the relationship between genotype and PTSS. These results highlight the role of PCC in distress following trauma.

Indexed as

GenotypePolymorphism, GeneticSurvivorsAdultAllelesFemaleGenetic MarkersHumansMagnetic Resonance ImagingMaleMiddle AgedSeptember 11 Terrorist AttacksSerotonin Plasma Membrane Transport ProteinsSocial BehaviorStress Disorders, Post-TraumaticGenetic MarkersSerotonin Plasma Membrane Transport Proteins9/11fMRIpolymorphismposterior cingulate cortexpost-traumatic stresstrauma

Identifiers

PMID25338633
PMCPMC4448027

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