Evidence map›Paper›PMID 25338631›Full record

ArticleSocial cognitive and affective neuroscience2015

Effect of brain structure and function on reward anticipation in children and adults with attention deficit hyperactivity disorder combined subtype.

Viola Kappel, Robert C Lorenz, Martina Streifling, Babette Renneberg, Ulrike Lehmkuhl, Andreas Ströhle, Harriet Salbach-Andrae, Anne Beck

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Social cognitive and affective neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 5 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 5 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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  15. Top-Down Dysregulation-From ADHD to Emotional Instability.Frontiers in behavioral neuroscience · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Viola KappelDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany, Clinical Psychology and Psychotherapy, Freie Universität Berlin, Habelschwerdter Allee 45, D-14195 Berlin, Germany, Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany, and Department of Psychology, Humboldt Universität zu Berlin, Rudower Chaussee 18, D-12489 Berlin, Germany Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany, Clinical Psychology and Psychotherapy, Freie Universität Berlin, Habelschwerdter Allee 45, D-14195 Berlin, Germany, Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany, and Department of Psychology, Humboldt Universität zu Berlin, Rudower Chaussee 18, D-12489 Berlin, Germany viola.kappel@charite.de.
Robert C LorenzDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany, Clinical Psychology and Psychotherapy, Freie Universität Berlin, Habelschwerdter Allee 45, D-14195 Berlin, Germany, Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany, and Department of Psychology, Humboldt Universität zu Berlin, Rudower Chaussee 18, D-12489 Berlin, Germany Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany, Clinical Psychology and Psychotherapy, Freie Universität Berlin, Habelschwerdter Allee 45, D-14195 Berlin, Germany, Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany, and Department of Psychology, Humboldt Universität zu Berlin, Rudower Chaussee 18, D-12489 Berlin, Germany.
Martina StreiflingDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany, Clinical Psychology and Psychotherapy, Freie Universität Berlin, Habelschwerdter Allee 45, D-14195 Berlin, Germany, Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany, and Department of Psychology, Humboldt Universität zu Berlin, Rudower Chaussee 18, D-12489 Berlin, Germany.
Babette RennebergDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany, Clinical Psychology and Psychotherapy, Freie Universität Berlin, Habelschwerdter Allee 45, D-14195 Berlin, Germany, Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany, and Department of Psychology, Humboldt Universität zu Berlin, Rudower Chaussee 18, D-12489 Berlin, Germany.
Ulrike LehmkuhlDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany, Clinical Psychology and Psychotherapy, Freie Universität Berlin, Habelschwerdter Allee 45, D-14195 Berlin, Germany, Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany, and Department of Psychology, Humboldt Universität zu Berlin, Rudower Chaussee 18, D-12489 Berlin, Germany.
Andreas StröhleDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany, Clinical Psychology and Psychotherapy, Freie Universität Berlin, Habelschwerdter Allee 45, D-14195 Berlin, Germany, Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany, and Department of Psychology, Humboldt Universität zu Berlin, Rudower Chaussee 18, D-12489 Berlin, Germany.
Harriet Salbach-AndraeDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany, Clinical Psychology and Psychotherapy, Freie Universität Berlin, Habelschwerdter Allee 45, D-14195 Berlin, Germany, Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany, and Department of Psychology, Humboldt Universität zu Berlin, Rudower Chaussee 18, D-12489 Berlin, Germany.
Anne BeckDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany, Clinical Psychology and Psychotherapy, Freie Universität Berlin, Habelschwerdter Allee 45, D-14195 Berlin, Germany, Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany, and Department of Psychology, Humboldt Universität zu Berlin, Rudower Chaussee 18, D-12489 Berlin, Germany.
Charité - Universitätsmedizin Berlin · DEFreie Universität Berlin · DEHumboldt-Universität zu Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Attention deficit hyperactivity disorder (ADHD) is associated with decreased ventral-striatal responsiveness during reward anticipation. However, previous research mostly focused on adults with heterogeneous ADHD subtype and divers drug treatment status while studies in children with ADHD are sparse. Moreover, it remains unclear to what degree ADHD is characterized by a delay of normal brain structure or function maturation. We therefore attempt to determine whether results from structural and functional magnetic resonance imaging (fMRI) are associated with childhood and adult ADHD combined subtype (ADHD-CT). This study used fMRI to compare VS structure and function of 30 participants with ADHD-CT (16 adults, 14 children) and 30 controls (20 adults, 10 children), using a monetary incentive delay task. Joint analyses of structural and functional imaging data were conducted with Biological Parametric Mapping. Reward anticipation elicited decreased ventral-striatal responsiveness in adults but not in children with ADHD-CT. Children and adults with ADHD showed reduced ventral-striatal volume. Taking these gray matter differences into account, the results remained the same. These results suggest that decreased ventral-striatal responsiveness during reward anticipation is present in adults but not in children with ADHD-CT, irrespective of structural characteristics. The question arises whether ventral-striatal hypoactivity is an ADHD correlate that develops during the course of illness.

Indexed as

Anticipation, PsychologicalRewardAdolescentAdultAttention Deficit Disorder with HyperactivityBrainBrain MappingChildFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMalePsychiatric Status Rating ScalesReaction TimeVentral StriatumADHDreward anticipationventral striatum

Identifiers

PMID25338631
PMCPMC4483558
OpenAlexW2149743275

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.