ArticleJournal of clinical hypertension (Greenwich, Conn.)2015
Resistant hypertension: risk factors, subclinical atherosclerosis, and comorbidities among adults-the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
Article in Journal of clinical hypertension (Greenwich, Conn.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- The highly neglected burden of resistant hypertension in Africa: a systematic review and meta-analysis.BMJ open · 2016Pooled it
- Validating the Framingham Hypertension Risk Score: A 4-year follow-up from the Brazilian Longitudinal Study of the Adult Health (ELSA-Brasil).Journal of clinical hypertension (Greenwich, Conn.) · 2020Trial
- Low dose-eplerenone treatment decreases aortic stiffness in patients with resistant hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2017Trial
- Beyond the Scale: Obesity as a Structural Driver of Refractory Hypertension.Arquivos brasileiros de cardiologia · 2026Article
- Association between HIV and treatment-resistant hypertension in Malawian adults: a protocol for a case-control study.BMJ open · 2023Article
- Lobar intracerebral hemorrhage and risk of subsequent uncontrolled blood pressure.European stroke journal · 2022Article
- Clinical Characteristics of Resistant vs. Refractory Hypertension in a Population of Hypertensive Afrodescendants.Arquivos brasileiros de cardiologia · 2020Article
- Cystatin C, vascular biomarkers and measured glomerular filtration rate in patients with unresponsive hypertensive phenotype: a pilot study.Renal failure · 2017Article
- Leisure-time and commuting physical activity and high blood pressure: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).Journal of human hypertension · 2017Article
- MCP-1 Levels are Associated with Cardiac Remodeling but not with Resistant Hypertension.Arquivos brasileiros de cardiologia · 2017Observational
- Factors associated with the use of antihypertensives among seniors.Revista de saude publica · 2016Article
- Stroke Prevention in Atrial Fibrillation: Focus on Latin America.Arquivos brasileiros de cardiologia · 2016Review
- Untreated, Uncontrolled, and Apparent Resistant Hypertension: Results of the German Health Examination Survey 2008-2011.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Increasing The Genetic Admixture of Available Lines of Human Pluripotent Stem Cells.Scientific reports · 2016Article
- Increased Circulating Tissue Inhibitor of Metalloproteinase-2 Is Associated With Resistant Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Hemodynamic and Arterial Stiffness Parameters in Ambulatory Blood Pressure Phenotypes and the Clinical Scenario of Polypharmacy and Comorbidities.Journal of clinical hypertension (Greenwich, Conn.) · 2015Article
- Knowing for whom the bell tolls: acting locally and thinking globally. Brazil, Latin America and the Global Burden of Diseases, 2015.Sao Paulo medical journal = Revista paulista de medicinaArticle
- Resistant and refractory hypertension: two sides of the same disease?Jornal brasileiro de nefrologiaArticle
- Carotid intima-media thickness in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): a narrative review.Sao Paulo medical journal = Revista paulista de medicinaReview
- Brazilian Position Statement on Resistant Hypertension - 2020.Arquivos brasileiros de cardiologiaArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The frequency of resistant hypertension-defined as blood pressure (BP) ≥140/90 mm Hg with proven use of three antihypertensive medications, or as the use of four antihypertensive drug classes regardless of BP-is unknown in low-middle-income countries. Using data from the Brazilian Longitudinal Study of Adult Health, a cohort of 15,105 civil servants aged 35 to 74 years, the authors identified 4116 patients taking treatment for hypertension, 11% of who had resistant hypertension. These participants were more likely to be older, black, less educated, poorer, and obese. The adjusted prevalence ratios (95% confidence intervals) were diabetes, 1.44 (1.20-1.72); glomerular filtration rate (<60 mL/min/1.72 m(2) ), 1.95 (1.60-2.38); albumin-to-creatinine ratio (>300 mg/g), 2.43 (1.70-3.50); carotid-femoral pulse-wave velocity, 1.07 m/s (1.03-1.11 m/s); common carotid intima-media thickness, 2.57 mm (1.64-4.00 mm); left ventricular hypertrophy, 2.08 (1.21-3.57); and atrial fibrillation, 3.55 (2.02-6.25). Thus, the prevalence of resistant hypertension in Brazil is high and associated with subclinical markers of end-organ cardiovascular damage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.