ArticleJournal of natural products2014
Chlorinated polyketide obtained from a Daldinia sp. treated with the epigenetic modifier suberoylanilide hydroxamic acid.
Article in Journal of natural products, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Enhancement hispolon production from Phellinus linteus via epigenetic-modified culture to inhibit human breast cancer cells.Biotechnology letters · 2025Article
- Structures and Biological Activities of Secondary Metabolites fromJournal of fungi (Basel, Switzerland) · 2024Review
- [Using metabolomics to explore the effects of epigenetic-modification strategies on the metabolites ofSe pu = Chinese journal of chromatography · 2024Article
- Epigenetic modifiers as inducer of bioactive secondary metabolites in fungi.Biotechnology letters · 2024Review
- Recent Advances in Search of Bioactive Secondary Metabolites from Fungi Triggered by Chemical Epigenetic Modifiers.Journal of fungi (Basel, Switzerland) · 2023Review
- Metabolomic Strategy to Characterize the Profile of Secondary Metabolites inMolecules (Basel, Switzerland) · 2022Article
- Rapid Access to Hydroxyfluoranthenes via a Domino Suzuki-Miyaura/Intramolecular Diels-Alder/Ring-Opening Reactions Sequence.The Journal of organic chemistry · 2022Article
- Building Natural Product Libraries Using Quantitative Clade-Based and Chemical Clustering Strategies.mSystems · 2021Article
- Media and strain studies for the scaled production of cis-enone resorcylic acid lactones as feedstocks for semisynthesis.The Journal of antibiotics · 2021Article
- Enhanced Production and Anticancer Properties of Photoactivated Perylenequinones.Journal of natural products · 2020Article
- Article
- On top of biosynthetic gene clusters: How epigenetic machinery influences secondary metabolism in fungi.Biotechnology advances · 2019Review
- Bortezomib-induced new bergamotene derivatives xylariterpenoids H-K from sponge-derived fungusRSC advances · 2019Article
- Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review.Frontiers in microbiology · 2019Review
- Antimicrobial Metabolites Produced byFrontiers in microbiology · 2019Article
- Omics based approach for biodiscovery of microbial natural products in antibiotic resistance era.Journal, genetic engineering & biotechnology · 2018Review
- Dynamics of Metabolite Induction in Fungal Co-cultures by Metabolomics at Both Volatile and Non-volatile Levels.Frontiers in microbiology · 2018Article
- Article
- NADAMB Express · 2017Article
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Authors and funding
3 authors.
Funding
Abstract
A new chlorinated pentacyclic polyketide, daldinone E (1), was purified from a Daldinia sp. fungal isolate treated with the epigenetic modifier suberoylanilide hydroxamic acid (SAHA). A biosynthetically related epoxide-containing daldinone analogue, 2, was also purified from the same fungus. The structures of both compounds were established by spectroscopic methods, and the absolute configurations were assigned by analysis of their NMR data (coupling constants and ROESY correlations) and DFT calculations of specific rotations and ECD spectra. During the course of these studies it was determined that metabolite 2 and the previously reported daldinone B shared the same spectroscopic data, leading to a revision of the reported structure. Both compounds 1 and 2 also exhibited DPPH radical scavenging activities with potency comparable to the positive control ascorbic acid.
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Registered trials
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