ArticleEnvironmental science & technology2014
Comparative and mechanistic genotoxicity assessment of nanomaterials via a quantitative toxicogenomics approach across multiple species.
Article in Environmental science & technology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 95 citations in OpenAlex.
- Protein Biomarkers of DNA Damage in Yeast Cells for Genotoxicity Screening.Environment & health (Washington, D.C.) · 2025Article
- Long-term impact of Hurricane Maria on point-of-use drinking water quality in Puerto Rico and associated potential adverse health effects.Water research · 2024Article
- Amplified and distinctive genotoxicity of titanium dioxide nanoparticles in transformed yeast reporters with human cytochrome P450 (CYP) genes.Journal of hazardous materials · 2024Article
- Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis.Acta pharmaceutica Sinica. B · 2023Article
- Machine learning-based biomarkers identification from toxicogenomics - Bridging to regulatory relevant phenotypic endpoints.Journal of hazardous materials · 2022Article
- Direct and Indirect Genotoxicity of Graphene Family Nanomaterials on DNA-A Review.Nanomaterials (Basel, Switzerland) · 2021Review
- Dependence of Graphene Oxide (GO) Toxicity on Oxidation Level, Elemental Composition, and Size.International journal of molecular sciences · 2021Article
- Comparative and mechanistic toxicity assessment of structure-dependent toxicity of carbon-based nanomaterials.Journal of hazardous materials · 2021Article
- GFP-fused yeast cells as whole-cell biosensors for genotoxicity evaluation of nitrosamines.Applied microbiology and biotechnology · 2021Article
- Environmental risk of nanomaterials and nanoparticles and EPR technique as an effective tool to study them-a review.Environmental science and pollution research international · 2021Review
- Environmentally Induced Changes of Commercial Carbon Nanotubes in Aqueous Suspensions. Adaptive Behavior of Bacteria in Biofilms.ACS omega · 2021Article
- Novel Drug Delivery Systems Fighting Glaucoma: Formulation Obstacles and Solutions.Pharmaceutics · 2020Review
- Genotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment-A Review.Nanomaterials (Basel, Switzerland) · 2020Review
- Impact of Hurricane Maria on Drinking Water Quality in Puerto Rico.Environmental science & technology · 2020Article
- Nanotoxicity: a challenge for future medicineTurkish journal of medical sciences · 2020Review
- Toxicity of Single-Walled Carbon Nanotubes (SWCNTs): Effect of Lengths, Functional Groups and Electronic Structures Revealed by a Quantitative Toxicogenomics Assay.Environmental science. Nano · 2020Article
- Multi-walled carbon nanotubes upregulate mitochondrial gene expression and trigger mitochondrial dysfunction in primary human bronchial epithelial cells.Nanotoxicology · 2019Article
- The response of Escherichia coli to the alkylating agents chloroacetaldehyde and styrene oxide.Mutation research. Genetic toxicology and environmental mutagenesis · 2019Article
- Genotoxicity Assessment of Drinking Water Disinfection Byproducts by DNA Damage and Repair Pathway Profiling Analysis.Environmental science & technology · 2018Article
- Toxicity Effects of Functionalized Quantum Dots, Gold and Polystyrene Nanoparticles on Target Aquatic Biological Models: A Review.Molecules (Basel, Switzerland) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
This study reports a comparative and mechanistic genotoxicity assessment of four engineered nanomaterials (ENMs) across three species, including E. coli, yeast, and human cells, with the aim to reveal the distinct potential genotoxicity mechanisms among the different nanomaterials and their association with physiochemical features. Both the conventional phenotypic alkaline comet test and the newly developed quantitative toxicogenomics assay, that detects and quantifies molecular level changes in the regulation of six DNA damage repair pathways, were employed. The proposed molecular endpoints derived from the toxicogenomics assays, namely TELI (Transcriptional Effect Level Index) and PELI (Protein Effect Level Index), correlated well with the phenotypic DNA damage endpoints from comet tests, suggesting that the molecular genotoxicity assay is suitable for genotoxicity detection. Temporal altered gene or protein expression profiles revealed various potential DNA damage types and relevant genotoxic mechanisms induced by the tested ENMs. nTiO2_a induced a wide spectrum of DNA damage consistently across three species. Three carbon-based ENMs, namely carbon black, single wall carbon nanotube (SWCNT) and fullerene, exhibited distinct, species and ENM property-dependent DNA damage mechanisms. All carbon based ENMs induced relatively weak DNA damage repair response in E. coli, but more severe DNA double strand break in eukaryotes. The differences in cellular structure and defense systems among prokaryotic and eukaryotic species lead to distinct susceptibility and mechanisms for ENM uptake and, thus, varying DNA damages and repair responses. The observation suggested that eukaryotes, especially mammalian cells, are likely more susceptible to genotoxicity than prokaryotes in the ecosystem when exposed to these ENMs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.